ETR1/YBR026C Protein Information

Standard Name	Etr1p
Systematic Name	Ybr026cp
Alias	Mrf1p , Mrf1'p
ORF Classification	Verified
Description	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis (1)
Name Description	2-Enoyl Thioester Reductase
Gene Product	2-enoyl thioester reductase, E.C. 1.3.1.- 1

Experimental Data
Molecules/cell	1560 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	380
Molecular Weight (Da)	42,067
Isoelectric Point (pI)	9.78

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Etr1p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001682BA \| P38071 MIPS: YBR026C NCBI: 116241357 \| 45269635 \| 456171 \| 498755 \| 536236 \| 6319500 \| 730061 \| NP_009582.1 GenBank/EMBL/DDBJ: DAA07148.1 \| AY557872 \| D26606 \| X76078 \| Z35895
External Classifications	EC: 1.3.1.10 [Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)] EC: 1.3.1.38 [Trans-2-enoyl-CoA reductase (NADPH)]

Amino Acid Sequence (or in FASTA format)
1 MLPTFKRYMS SSAHQIPKHF KSLIYSTHEV EDCTKVLSVK NYTPKQDLSQ 51 SIVLKTLAFP INPSDINQLQ GVYPSRPEKT YDYSTDEPAA IAGNEGVFEV 101 VSLPSGSSKG DLKLGDRVIP LQANQGTWSN YRVFSSSSDL IKVNDLDLFS 151 AATVSVNGCT GFQLVSDYID WNSNGNEWII QNAGTSSVSK IVTQVAKAKG 201 IKTLSVIRDR DNFDEVAKVL EDKYGATKVI SESQNNDKTF AKEVLSKILG 251 ENARVRLALN SVGGKSSASI ARKLENNALM LTYGGMSKQP VTLPTSLHIF 301 KGLTSKGYWV TEKNKKNPQS KIDTISDFIK MYNYGHIISP RDEIETLTWN 351 TNTTTDEQLL ELVKKGITGK GKKKMVVLEW *

Amino Acid Sequence (or in FASTA format)

       1  MLPTFKRYMS SSAHQIPKHF KSLIYSTHEV EDCTKVLSVK NYTPKQDLSQ
      51  SIVLKTLAFP INPSDINQLQ GVYPSRPEKT YDYSTDEPAA IAGNEGVFEV
     101  VSLPSGSSKG DLKLGDRVIP LQANQGTWSN YRVFSSSSDL IKVNDLDLFS
     151  AATVSVNGCT GFQLVSDYID WNSNGNEWII QNAGTSSVSK IVTQVAKAKG
     201  IKTLSVIRDR DNFDEVAKVL EDKYGATKVI SESQNNDKTF AKEVLSKILG
     251  ENARVRLALN SVGGKSSASI ARKLENNALM LTYGGMSKQP VTLPTSLHIF
     301  KGLTSKGYWV TEKNKKNPQS KIDTISDFIK MYNYGHIISP RDEIETLTWN
     351  TNTTTDEQLL ELVKKGITGK GKKKMVVLEW *

external links for Etr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Etr1p

1)	Torkko JM, et al. (2001) Candida tropicalis Etr1p and Saccharomyces cerevisiae Ybr026p (Mrf1'p), 2-enoyl thioester reductases essential for mitochondrial respiratory competence. Mol Cell Biol 21(18):6243-53
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41