SCO2/YBR024W Protein Information

Standard Name	Sco2p
Systematic Name	Ybr024wp
ORF Classification	Verified
Description	Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication (1, 2)
Name Description	Suppressor of Cytochrome Oxidase deficiency 3

Experimental Data
Molecules/cell	1480 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	301
Molecular Weight (Da)	34,888
Isoelectric Point (pI)	8.11

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sco2p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013566E \| P38072 MIPS: YBR024W NCBI: 498753 \| 536232 \| 585972 \| 6319498 \| NP_009580.1 GenBank/EMBL/DDBJ: DAA07146.1 \| X76078 \| Z35893

Amino Acid Sequence (or in FASTA format)
1 MLNSSRKYAC RSLFRQANVS IKGLFYNGGA YRRGFSTGCC LRSDNKESPS 51 ARQPLDRLQL GDEINEPEPI RTRFFQFSRW KATIALLLLS GGTYAYLSRK 101 RRLLETEKEA DANRAYGSVA LGGPFNLTDF NGKPFTEENL KGKFSILYFG 151 FSHCPDICPE ELDRLTYWIS ELDDKDHIKI QPLFISCDPA RDTPDVLKEY 201 LSDFHPAIIG LTGTYDQVKS VCKKYKVYFS TPRDVKPNQD YLVDHSIFFY 251 LIDPEGQFID ALGRNYDEQS GLEKIREQIQ AYVPKEERER RSKKWYSFIF 301 N*

Amino Acid Sequence (or in FASTA format)

       1  MLNSSRKYAC RSLFRQANVS IKGLFYNGGA YRRGFSTGCC LRSDNKESPS
      51  ARQPLDRLQL GDEINEPEPI RTRFFQFSRW KATIALLLLS GGTYAYLSRK
     101  RRLLETEKEA DANRAYGSVA LGGPFNLTDF NGKPFTEENL KGKFSILYFG
     151  FSHCPDICPE ELDRLTYWIS ELDDKDHIKI QPLFISCDPA RDTPDVLKEY
     201  LSDFHPAIIG LTGTYDQVKS VCKKYKVYFS TPRDVKPNQD YLVDHSIFFY
     251  LIDPEGQFID ALGRNYDEQS GLEKIREQIQ AYVPKEERER RSKKWYSFIF
     301  N*

external links for Sco2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sco2p

1)	Lode A, et al. (2002) Molecular characterization of Saccharomyces cerevisiae Sco2p reveals a high degree of redundancy with Sco1p. Yeast 19(11):909-22
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Glerum DM, et al. (1996) SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J Biol Chem 271(34):20531-5
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41