FUR4/YBR021W Protein Information Help

Standard Name Fur4p
Systematic Name Ybr021wp
ORF Classification Verified
Description Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation (1, 2, 3, 4)
Name Description 5-FlUoRouridine sensitivity 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 633
Molecular Weight (Da) 71,735
Isoelectric Point (pI) 7.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Fur4p (InterPro)
Transmembrane Domains There are 13 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012AD73 | P05316
MIPS: YBR021W
NCBI: 3706 | 498750 | 536226 | 585161 | 6319495 | NP_009577.1
GenBank/EMBL/DDBJ: DAA07143.1 | X06830 | X76078 | Z35890
External Classifications TC: 2.A.39.3
Amino Acid Sequence (or in FASTA format)
 
       1  MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE
      51  VYEASSFEEK VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD
     101  LKPVEKERRV WSWYNYCYFW LAECFNINTW QIAATGLQLG LNWWQCWITI
     151  WIGYGFVGAF VVLASRVGSA YHLSFPISSR ASFGIFFSLW PVINRVVMAI
     201  VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT TYEFMCFFIF
     251  WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL
     301  TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL
     351  VCIPFLFSIT CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA
     401  GVFLISFVFA VAQLGTNISA NSLSCGTDMS AIFPKFINIK RGSLFCAAMA
     451  LCICPWNLMA TSSKFTMALS AYAIFLSSIA GVVCSDYFVV RRGYIKLTHI
     501  YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV GAPAIKVSDG
     551  AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV
     601  DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI*

external links for Fur4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome TCDB
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Fur4p
1) Pinson B, et al.  (1999) Only one of the charged amino acids located in membrane-spanning regions is important for the function of the Saccharomyces cerevisiae uracil permease. Biochem J 339 ( Pt 1)():37-42
2) Seron K, et al.  (1999) Uracil-induced down-regulation of the yeast uracil permease. J Bacteriol 181(6):1793-800
3) Hearn JD, et al.  (2003) The uracil transporter Fur4p associates with lipid rafts. J Biol Chem 278(6):3679-86
4) Keener JM and Babst M  (2013) Quality control and substrate-dependent downregulation of the nutrient transporter fur4. Traffic 14(4):412-27
5) Jund R and Lacroute F  (1970) Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae. J Bacteriol 102(3):607-15