MNN2/YBR015C Protein Information Help

Standard Name Mnn2p 1
Systematic Name Ybr015cp
Alias Ttp1p , Crv4p , Ldb8p
ORF Classification Verified
Description Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment (2)
Name Description MaNNosyltransferase
Experimental Data
Molecules/cell 6730 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 597
Molecular Weight (Da) 67,773
Isoelectric Point (pI) 6.18

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mnn2p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001377AB | P38069
MIPS: YBR015C
NCBI: 500628 | 536214 | 586137 | 6319489 | NP_009571.1
GenBank/EMBL/DDBJ: DAA07137.1 | U05211 | Z35884
External Classifications EC: 2.4.1.- [Hexosyltransferases]
Amino Acid Sequence (or in FASTA format)
 
       1  MLLTKRFSKL FKLTFIVLIL CGLFVITNKY MDENTSVKEY KEYLDRYVQS
      51  YSNKYSSSSD AASADDSTPL RDNDEAGNEK LKSFYNNVFN FLMVDSPKGS
     101  TAKQYNEACL LKGDIGDRPD HYKDLYKLSA KELSKCLELS PDEVASLTKS
     151  HKDYVEHIAT LVSPKGTYKG SGIATVGGGK FSLMAFLIIK TLRNMGTTLP
     201  VEVLIPPGDE GETEFCNKIL PKYNSKCIYV SDILPRETIE KFVFKGYQFK
     251  SLALIASSFE NLLLLDADNF PIKPLDNIFN EEPYVSTGLV MWPDFWRRTT
     301  HPLYYDIAGI AVDKKKRVRN SRDDITPPAV YTKDLKDLSD VPLSDLDGTI
     351  PDVSTESGQL MINKTKHLAT ALLSLFYNVN GPTWYYPIFS QKAAGEGDKE
     401  TFIAAANFYG LSFYQVRTRT GVEGYHDEDG FHGVAMLQHD FVQDYGRYLN
     451  AMESIGNKYG GTKSADAIKF DKNYSLEKYT EEFFDNEDLN AKNHVDVMFI
     501  HSNFPKFDPY DLSKSNFLTT NGKPARSYTA LKKVKNYDIE LENFKVLNEY
     551  VCVNKNPFKY LDDLLGQDKT EWKRVCGYIT DRLAFLESTH DKAIAGK*

external links for Mnn2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Aspergillus (AspGD) CYC2008 (complexes) Pfam domains
Candida (CGD) Complexome YeastRC Structure Prediction (Seattle)
Candida (CandidaDB) DIP

YGOB GeneMANIA

YOGY YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mnn2p
1) Raschke WC, et al.  (1973) Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants. J Biol Chem 248(13):4660-6
2) Rayner JC and Munro S  (1998) Identification of the MNN2 and MNN5 mannosyltransferases required for forming and extending the mannose branches of the outer chain mannans of Saccharomyces cerevisiae. J Biol Chem 273(41):26836-43
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41