GRX7/YBR014C Protein Information

Standard Name	Grx7p 1, 2
Systematic Name	Ybr014cp
ORF Classification	Verified
Description	Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	GlutaRedoXin 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	203
Molecular Weight (Da)	22,565
Isoelectric Point (pI)	5.91

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Grx7p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A3B2 \| P38068 MIPS: YBR014C NCBI: 536212 \| 586473 \| 6319488 \| 91984094 \| NP_009570.1 GenBank/EMBL/DDBJ: DAA07136.1 \| DQ462165 \| Z35883

Amino Acid Sequence (or in FASTA format)
1 MAIVINKRNV RVLVITNLLL IVVFFVLRNS NASVNESITT HHPDSLVTFD 51 NSGNAPGTHQ SVHDTVNTQD KEAEEVDKNS GDAEFDAAAE YNKIMEQSPM 101 IVFSKTGCPY SKKLKALLTN SYTFSPSYYV VELDRHEHTK ELQDQIEKVT 151 GRRTVPNVII GGTSRGGYTE IAELHKNDEL LDSFKKWSDG AFTVKANSQS 201 ESA*

Amino Acid Sequence (or in FASTA format)

       1  MAIVINKRNV RVLVITNLLL IVVFFVLRNS NASVNESITT HHPDSLVTFD
      51  NSGNAPGTHQ SVHDTVNTQD KEAEEVDKNS GDAEFDAAAE YNKIMEQSPM
     101  IVFSKTGCPY SKKLKALLTN SYTFSPSYYV VELDRHEHTK ELQDQIEKVT
     151  GRRTVPNVII GGTSRGGYTE IAELHKNDEL LDSFKKWSDG AFTVKANSQS
     201  ESA*

external links for Grx7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Grx7p

1)	Mesecke N, et al. (2008) Two Novel Monothiol Glutaredoxins from Saccharomyces cerevisiae Provide Further Insight into Iron-Sulfur Cluster Binding, Oligomerization, and Enzymatic Activity of Glutaredoxins. Biochemistry 47(5):1452-63
2)	Izquierdo A, et al. (2008) Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway. Eukaryot Cell 7(8):1415-26
3)	Fetrow JS, et al. (2001) Genomic-scale comparison of sequence- and structure-based methods of function prediction: does structure provide additional insight? Protein Sci 10(5):1005-14
4)	Terashima H, et al. (2002) Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae. Curr Genet 40(5):311-6
5)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6)	Mesecke N, et al. (2008) A Novel Group of Glutaredoxins in the cis-Golgi Critical for Oxidative Stress Resistance. Mol Biol Cell 19(6):2673-80