HHF1/YBR009C Protein Information Help

Standard Name Hhf1p
Systematic Name Ybr009cp
ORF Classification Verified
Description Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity (1, 2, 3, 4, 5, 6)
Name Description Histone H Four
Experimental Data
Molecules/cell 524000 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 103
Molecular Weight (Da) 11,368
Isoelectric Point (pI) 11.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hhf1p (InterPro)
Physical Interactions There are 721 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F8D3 | P02309
MIPS: YBR009C
NCBI: 11513448 | 119389631 | 122107 | 1301868 | 158430380 | 158430382 | 15988133 | 15988137 | 162329885 | 162329886 | 171639 | 326327711 | 356624623 | 3756 | 3759 | 50513648 | 50513650 | 51013371 | 536202 | 6319481 | 6324298 | NP_009563.1 | NP_014368.1
GenBank/EMBL/DDBJ: DAA07130.1 | DAA10515.1 | AY692960 | K03154 | X00724 | X00725 | Z35878 | Z71306
Amino Acid Sequence (or in FASTA format)
 
       1  MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISGL
      51  IYEEVRAVLK SFLESVIRDS VTYTEHAKRK TVTSLDVVYA LKRQGRTLYG
     101  FGG*

external links for Hhf1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CGD) Complexome YeastRC Structure Prediction (Seattle)
Candida (CandidaDB) DIP

Candida (CandidaDB) GeneMANIA

YGOB YeastRC Mass Spec (Seattle)

YOGY


References cited on this page View Complete Literature Guide for Hhf1p
1) Megee PC, et al.  (1995) Histone H4 and the maintenance of genome integrity. Genes Dev 9(14):1716-27
2) Wyrick JJ, et al.  (1999) Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature 402(6760):418-21
3) Smith MM, et al.  (1996) A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission. Mol Cell Biol 16(3):1017-26
4) Smith MM and Andresson OS  (1983) DNA sequences of yeast H3 and H4 histone genes from two non-allelic gene sets encode identical H3 and H4 proteins. J Mol Biol 169(3):663-90
5) Grunstein M  (1990) Histone function in transcription. Annu Rev Cell Biol 6:643-78
6) Altheim BA and Schultz MC  (1999) Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(4):1345-50
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41