UGA2/YBR006W Protein Information

Standard Name	Uga2p 1
Systematic Name	Ybr006wp
Alias	Uga5p 2
ORF Classification	Verified
Description	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm (1, 3)
Name Description	Utilization of GAba 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	497
Molecular Weight (Da)	54,189
Isoelectric Point (pI)	6.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Uga2p (InterPro)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000137AE7 \| P38067 MIPS: YBR006W NCBI: 4388565 \| 4388567 \| 6136604 \| 6319478 \| NP_009560.1 GenBank/EMBL/DDBJ: DAA07127.1 \| Z35875 \| Z35876
External Classifications	EC: 1.2.1.16 [Succinate-semialdehyde dehydrogenase (NAD(P)(+))]

Amino Acid Sequence (or in FASTA format)
1 MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP 51 EQPVSVVEEA IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI 101 ITLENGKALG EAKGEIKYAA SYFEWYAEEA PRLYGATIQP LNPHNRVFTI 151 RQPVGVCGII CPWNFPSAMI TRKAAAALAV GCTVVIKPDS QTPLSALAMA 201 YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF TGSTNVGKIL 251 MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC 301 ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE 351 RHKQDAIDKG AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP 401 LCPIFSFDTM EEVVGYANDT EFGLAAYVFS KNVNTLYTVS EALETGMVSC 451 NTGVFSDCSI PFGGVKESGF GREGSLYGIE DYTVLKTITI GNLPNSI*

Amino Acid Sequence (or in FASTA format)

       1  MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP
      51  EQPVSVVEEA IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI
     101  ITLENGKALG EAKGEIKYAA SYFEWYAEEA PRLYGATIQP LNPHNRVFTI
     151  RQPVGVCGII CPWNFPSAMI TRKAAAALAV GCTVVIKPDS QTPLSALAMA
     201  YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF TGSTNVGKIL
     251  MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC
     301  ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE
     351  RHKQDAIDKG AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP
     401  LCPIFSFDTM EEVVGYANDT EFGLAAYVFS KNVNTLYTVS EALETGMVSC
     451  NTGVFSDCSI PFGGVKESGF GREGSLYGIE DYTVLKTITI GNLPNSI*

external links for Uga2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Uga2p

1)	Ramos F, et al. (1985) Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem 149(2):401-4
2)	Coleman ST, et al. (2001) Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276(1):244-50
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91