RER2/YBR002C Protein Information

Standard Name	Rer2p 1
Systematic Name	Ybr002cp
ORF Classification	Verified
Description	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting (2)
Name Description	Retention in the Endoplasmic Reticulum 1

Experimental Data
Molecules/cell	8970 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	286
Molecular Weight (Da)	32,693
Isoelectric Point (pI)	7.79

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rer2p (InterPro)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000038E51 \| P35196 MIPS: YBR002C NCBI: 403317 \| 4126457 \| 465535 \| 536188 \| 6319474 \| NP_009556.1 GenBank/EMBL/DDBJ: DAA07123.1 \| AB013497 \| Z26494 \| Z35871
External Classifications	EC: 2.5.1.- [Transferases transferring alkyl or aryl groups, other than methyl groups]

Amino Acid Sequence (or in FASTA format)
1 METDSGIPGH SFVLKWTKNI FSRTLRASNC VPRHVGFIMD GNRRFARKKE 51 MDVKEGHEAG FVSMSRILEL CYEAGVDTAT VFAFSIENFK RSSREVESLM 101 TLARERIRQI TERGELACKY GVRIKIIGDL SLLDKSLLED VRVAVETTKN 151 NKRATLNICF PYTGREEILH AMKETIVQHK KGAAIDESTL ESHLYTAGVP 201 PLDLLIRTSG VSRLSDFLIW QASSKGVRIE LLDCLWPEFG PIRMAWILLK 251 FSFHKSFLNK EYRLEEGDYD EETNGDPIDL KEKKLN*

Amino Acid Sequence (or in FASTA format)

       1  METDSGIPGH SFVLKWTKNI FSRTLRASNC VPRHVGFIMD GNRRFARKKE
      51  MDVKEGHEAG FVSMSRILEL CYEAGVDTAT VFAFSIENFK RSSREVESLM
     101  TLARERIRQI TERGELACKY GVRIKIIGDL SLLDKSLLED VRVAVETTKN
     151  NKRATLNICF PYTGREEILH AMKETIVQHK KGAAIDESTL ESHLYTAGVP
     201  PLDLLIRTSG VSRLSDFLIW QASSKGVRIE LLDCLWPEFG PIRMAWILLK
     251  FSFHKSFLNK EYRLEEGDYD EETNGDPIDL KEKKLN*

external links for Rer2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rer2p

1)	Nishikawa S and Nakano A (1993) Identification of a gene required for membrane protein retention in the early secretory pathway. Proc Natl Acad Sci U S A 90(17):8179-83
2)	Sato M, et al. (1999) The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis. Mol Cell Biol 19(1):471-83
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41