SRO77/YBL106C Protein Information Help

Standard Name Sro77p
Systematic Name Ybl106cp
Alias Sop2p 1 , Sni2p
ORF Classification Verified
Description Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Suppressor of rho3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,010
Molecular Weight (Da) 111,623
Isoelectric Point (pI) 8.88

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sro77p (InterPro)
Physical Interactions There are 16 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0001F7BD28 | P38163
MIPS: YBL106C
NCBI: 330443393 | 341942069 | 498989 | 536180 | 586462 | NP_009444.2 | NM_001178346.2
GenBank/EMBL/DDBJ: DAA07017.2 | X79489 | Z35867
Amino Acid Sequence (or in FASTA format)
 
       1  MFKKSRHLKN VSNAIKSARV HDVSNGINSK FFDTKKICTY GINGRITVTT
      51  FDYTQSLLAV ATTAGEIHVY GQKQIEVVFT LKNRPQIKHM RFIKGIYLIA
     101  VDEKSNIIVL SVHSKQILTT VFCPNSITCI ETDPSLDWML IGLESGSILI
     151  YDVDRNQMSK LKIENFQKSV FLPKERLSPV ISIQWNPRDI GTILISYEHI
     201  TVIYSFIDYK VKQHFFYQLE PYAPGGDLST NIEKKRTPKV IQSLYHPNSL
     251  HILTVHEDNS LVFWDVNSGK LIHARSIFET HVNFPNPALK DCSFTETPAI
     301  FKVSWLCQRN PEYTSLLIAT KATENPCLPQ EITMIDLGGT PMYSVTSFDA
     351  MSKYYAKPVQ QKLFSLIGKA PLINFLPLPK ASPYFGGCHD TNLILLLLED
     401  GELETLIYPA GSFSSKASIF PRSLAWVRPT VTTCIAQSVQ KNLWLGMMTI
     451  AQSESFLKGG IPATRNIRRH ETRSALLTGH SNGSVRIWDA SHSEVTDNAV
     501  FEVNTAKVLN RATNLAIKNI SFASETLELA VSSEVGDVIL FKFETNKFYG
     551  QLPKSDALQL KFSRFSLDDS KTILVDVSDR GPTNVKQGFI PSTVIHAKKG
     601  AVSAIMNSNI GFVAVGFIEG TLIILDRRGP AIIFNENIRV ISKAGSSYVS
     651  TVHFCVMEYG DDGFSSILML CGTDIGELMT FKILPATNGR FEVKFTDATK
     701  TNNQGKILGI NSFAKDTGYS CSATISKMQG LSKGIAIPGF VTISGANDIR
     751  LVSPGKSKDT HALFKYPIAT SGLSFIPIID GKGERKLSTI MIVLLINGDI
     801  KVLTVPELKE VKNLRCPVPL SAQYVENSSI LENGDIVIRT GKFQASLISV
     851  LNESATGTNH TADISQHTPI DTLYNPDLKI GYRPQVNSLQ WARGTIYCTP
     901  YQLDELLGGI ERPESKYEES AIARGCISSS SSNAARKLPP GTEDHRYARP
     951  VRSSGRSNGY GVLKSVSRAI ETRLDTVETT INDYATTMGQ TMNDAMEETG
    1001  RDMMKSAVGF *

external links for Sro77p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sro77p
1) Larsson K, et al.  (1998) The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene. J Biol Chem 273(50):33610-8
2) Lehman K, et al.  (1999) Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell Biol 146(1):125-40
3) Wadskog I, et al.  (2004) Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Mol Biol Cell 15(3):1436-44
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61