PKC1/YBL105C Protein Information

Standard Name	Pkc1p 1
Systematic Name	Ybl105cp
Alias	Cly15p , Hpo2p , Stt1p 2 , Cly5p 3 , Cly7p 3
ORF Classification	Verified
Description	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) (4, 5, 6)
Name Description	Protein Kinase C 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,151
Molecular Weight (Da)	131,476
Isoelectric Point (pI)	7.11

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pkc1p (InterPro)
Physical Interactions	There are 88 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001779D1D \| P24583 MIPS: YBL105C NCBI: 172177 \| 330443395 \| 341941028 \| 496664 \| 536178 \| 585365 \| NP_009445.2 \| NM_001178345.2 GenBank/EMBL/DDBJ: DAA07018.2 \| M32491 \| X79489 \| Z35866
External Classifications	EC: 2.7.11.13 [Protein kinase C]

Amino Acid Sequence (or in FASTA format)
1 MSFSQLEQNI KKKIAVEENI IRGASALKKK TSNVMVIQKC NTNIREARQN 51 LEYLEDSLKK LRLKTAQQSQ GENGSEDNER CNSKEYGFLS TKSPNEHIFS 101 RLDLVKYDCP SLAQRIQYML QQLEFKLQVE KQYQEANTKL TKLYQIDGDQ 151 RSSSAAEGGA MESKYRIQML NKALKKYQAI NVDFDQFKHQ PNDIMDNQQP 201 KFRRKQLTGV LTIGITAARD VDHIQSPMFA RKPESYVTIK IDDTIKARTK 251 PSRNDRWSED FQIPVEKGNE IEITVYDKVN DSLIPVAIMW LLLSDIAEEI 301 RKKKAGQTNE QQGWVNASNI NGGSSLASEE GSTLTSTYSN SAIQSTSAKN 351 VQGENTSTSQ ISTNSWFVLE PSGQILLTLG FHKSSQIERK QLMGGLHRHG 401 AIINRKEEIF EQHGHHFVQK SFYNIMCCAY CGDFLRYTGF QCQDCKFLCH 451 KKCYTNVVTK CIAKTSTDTD PDEAKLNHRI PHRFLPTSNR GTKWCCHCGY 501 ILPWGRHKVR KCSECGIMCH AQCAHLVPDF CGMSMEMANK ILKTIQDTKR 551 NQEKKKRTVP SAQLGSSIGT ANGSDLSPSK LAERANAPLP PQPRKHDKTP 601 SPQKVGRDSP TKQHDPIIDK RISLQTHGRE KLNKFIDENE AYLNFTEGAQ 651 QTAEFSSPEK TLDPTSNRRS LGLTDLSIEH SQTWESKDDL MRDELELWKA 701 QREEMELEIK QDSGEIQEDL EVDHIDLETK QKLDWENKND FREADLTIDS 751 THTNPFRDMN SETFQIEQDH ASKEVLQETV SLAPTSTHAS RTTDQQSPQK 801 SQTSTSAKHK KRAAKRRKVS LDNFVLLKVL GKGNFGKVIL SKSKNTDRLC 851 AIKVLKKDNI IQNHDIESAR AEKKVFLLAT KTKHPFLTNL YCSFQTENRI 901 YFAMEFIGGG DLMWHVQNQR LSVRRAKFYA AEVLLALKYF HDNGVIYRDL 951 KLENILLTPE GHIKIADYGL CKDEMWYGNR TSTFCGTPEF MAPEILKEQE 1001 YTKAVDWWAF GVLLYQMLLC QSPFSGDDED EVFNAILTDE PLYPIDMAGE 1051 IVQIFQGLLT KDPEKRLGAG PRDADEVMEE PFFRNINFDD ILNLRVKPPY 1101 IPEIKSPEDT SYFEQEFTSA PPTLTPLPSV LTTSQQEEFR GFSFMPDDLD 1151 L*

Amino Acid Sequence (or in FASTA format)

       1  MSFSQLEQNI KKKIAVEENI IRGASALKKK TSNVMVIQKC NTNIREARQN
      51  LEYLEDSLKK LRLKTAQQSQ GENGSEDNER CNSKEYGFLS TKSPNEHIFS
     101  RLDLVKYDCP SLAQRIQYML QQLEFKLQVE KQYQEANTKL TKLYQIDGDQ
     151  RSSSAAEGGA MESKYRIQML NKALKKYQAI NVDFDQFKHQ PNDIMDNQQP
     201  KFRRKQLTGV LTIGITAARD VDHIQSPMFA RKPESYVTIK IDDTIKARTK
     251  PSRNDRWSED FQIPVEKGNE IEITVYDKVN DSLIPVAIMW LLLSDIAEEI
     301  RKKKAGQTNE QQGWVNASNI NGGSSLASEE GSTLTSTYSN SAIQSTSAKN
     351  VQGENTSTSQ ISTNSWFVLE PSGQILLTLG FHKSSQIERK QLMGGLHRHG
     401  AIINRKEEIF EQHGHHFVQK SFYNIMCCAY CGDFLRYTGF QCQDCKFLCH
     451  KKCYTNVVTK CIAKTSTDTD PDEAKLNHRI PHRFLPTSNR GTKWCCHCGY
     501  ILPWGRHKVR KCSECGIMCH AQCAHLVPDF CGMSMEMANK ILKTIQDTKR
     551  NQEKKKRTVP SAQLGSSIGT ANGSDLSPSK LAERANAPLP PQPRKHDKTP
     601  SPQKVGRDSP TKQHDPIIDK RISLQTHGRE KLNKFIDENE AYLNFTEGAQ
     651  QTAEFSSPEK TLDPTSNRRS LGLTDLSIEH SQTWESKDDL MRDELELWKA
     701  QREEMELEIK QDSGEIQEDL EVDHIDLETK QKLDWENKND FREADLTIDS
     751  THTNPFRDMN SETFQIEQDH ASKEVLQETV SLAPTSTHAS RTTDQQSPQK
     801  SQTSTSAKHK KRAAKRRKVS LDNFVLLKVL GKGNFGKVIL SKSKNTDRLC
     851  AIKVLKKDNI IQNHDIESAR AEKKVFLLAT KTKHPFLTNL YCSFQTENRI
     901  YFAMEFIGGG DLMWHVQNQR LSVRRAKFYA AEVLLALKYF HDNGVIYRDL
     951  KLENILLTPE GHIKIADYGL CKDEMWYGNR TSTFCGTPEF MAPEILKEQE
    1001  YTKAVDWWAF GVLLYQMLLC QSPFSGDDED EVFNAILTDE PLYPIDMAGE
    1051  IVQIFQGLLT KDPEKRLGAG PRDADEVMEE PFFRNINFDD ILNLRVKPPY
    1101  IPEIKSPEDT SYFEQEFTSA PPTLTPLPSV LTTSQQEEFR GFSFMPDDLD
    1151  L*

external links for Pkc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pkc1p

1)	Levin DE, et al. (1990) A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell 62(2):213-24
2)	Yoshida S, et al. (1992) Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1. Mol Gen Genet 231(3):337-44
3)	Baymiller J and McCullough JE (1997) Saccharomyces cerevisiae cell lysis mutations cly5 and cly7 define temperature-sensitive alleles of PKC1, the gene encoding yeast protein kinase C. Yeast 13(4):305-12
4)	Levin DE, et al. (1994) Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res 40(3):229-39
5)	Andrews PD and Stark MJ (2000) Dynamic, Rho1p-dependent localization of Pkc1p to sites of polarized growth. J Cell Sci 113 ( Pt 15):2685-93
6)	Watanabe M, et al. (1994) Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC. J Biol Chem 269(24):16829-36