SEA4/YBL104C Protein Information Help

Standard Name Sea4p 1
Systematic Name Ybl104cp
Alias Ybl103c-ap
ORF Classification Verified
Description Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites (1, 2)
Name Description SEh1-Associated 1
Experimental Data
Molecules/cell 184 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,038
Molecular Weight (Da) 117,635
Isoelectric Point (pI) 6

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sea4p (InterPro)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000034F5BD | P38164
MIPS: YBL104C
NCBI: 30267768 | 41629671 | 496665 | 536176 | 84028282 | NP_009446.2 | NM_001178344.1
GenBank/EMBL/DDBJ: DAA07019.1 | AY260889 | X79489 | Z35865
Amino Acid Sequence (or in FASTA format)
 
       1  MGLIKKVTHW SYDNLIDYLS VNPTRDEVTH YKVDPENESD ESIIKLHTVK
      51  DFGSITCLDY SESEIGMIGV GEKNGYLRIF NISGQNSSSP ASHAPVGLNA
     101  NNETSMTNAS GGKAAQAENI VGSVSNLKDT QGYPVSETNY DIRVRAKKQR
     151  CINSLGINTN GLIAMGLDRN KHDSSLQIWD MNYHDDSHET INPMFSYCTN
     201  ESIVSLKFLN DTSVLAASTK FLKEIDVRSP NPIYQHPTRL TYDIKLNPFN
     251  DWQFSTYGDD GTLAIWDRRK LSDQASLGDL NVASPLLTFE KLVGSGAASR
     301  KYMNSCFRWS CVRNNEFATL HRGDTIKRWR LGYYCDSNRD IAADDDNEMN
     351  IENLFVSSVH DTNTMYDRVA TFDYIPRSNN GTSLICMRQS GTIYRMPISE
     401  VCSKAILNNR NSLLLSNFEN TEIDEIRVNN EHEKSNLENV KTILKNLSFE
     451  DLDVSEDYFP SGHDEPNNEI EYSELSEEEN EGSNDVLDSK RGFELFWKPE
     501  KLLEKDISVI MRTRASLGYG LDPMNTVEMI DSSKNLQNNA YIRNTWRWIA
     551  IAKASVDDGT MVSGDLDLGY EGVIGIWNGI NGISNQDRYR QETILSDKQL
     601  NKEMEKIIKL RRKNRDRNSP IANAAGSPKY VQRRLCLIIS GWDLSRSDYE
     651  DKYNIIMKNG HYEKAAAWAV FFGDIPKAVE ILGSAKKERL RLIATAIAGY
     701  LAYKDLPGNN AWRQQCRKMS SELDDPYLRV IFAFIADNDW WDILYEPAIS
     751  LRERLGVALR FLNDTDLTTF LDRTSSTVIE NGELEGLILT GITPNGIDLL
     801  QSYVNKTSDV QSAALISIFG SPRYFRDQRV DEWIQTYRDM LKSWELFSMR
     851  ARFDVLRSKL SRTKTGVLTA DIKPRQIYIQ CQNCKQNINT PRTSSPSSAV
     901  STSAGNYKNG EAYRRNNADY KKFNTGSSEA QAADEKPRHK YCCPHCGSSF
     951  PRCAICLMPL GTSNLPFVIN GTQSRDPMQT EDSQDGANRE LVSRKLKLNE
    1001  WFSFCLSCNH GMHAGHAEEW FDRHNVCPTP GCTCQCNK*

external links for Sea4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome

YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Sea4p
1) Dokudovskaya S, et al.  (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics 10(6):M110.006478
2) Schuldiner O, et al.  (1998) Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor. Curr Genet 33(1):16-20
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41