RTG3/YBL103C Protein Information

Standard Name	Rtg3p 1
Systematic Name	Ybl103cp
ORF Classification	Verified
Description	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways (2, 3)
Name Description	ReTroGrade regulation 1

Experimental Data
Molecules/cell	1050 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	486
Molecular Weight (Da)	54,139
Isoelectric Point (pI)	5.73

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rtg3p (InterPro)
Physical Interactions	There are 51 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001352D4 \| P38165 MIPS: YBL103C NCBI: 1177881 \| 1710804 \| 1870091 \| 1870092 \| 496666 \| 6319365 \| NP_009447.1 GenBank/EMBL/DDBJ: DAA07020.1 \| U46012 \| X79489 \| Z35864 \| Z35865

Amino Acid Sequence (or in FASTA format)
1 MMNNNESEAE NQRLLDELMN QTKVLQETLD FSLVTPTPHH NDDYKIHGSA 51 YPGGETPAQQ HEKLSYINTH NSNDNNNLMG SQARSNSQTP TASTIYEEAE 101 SQSSYLDDMF RTSQGGRPVT QNSISSIGQG PLRSSYSMAY DSPVDRAMNT 151 PLQQQEGLKA ELPHDFLFQH GTDDTMYNLT DDLSSSLSSS INSDMMTPNT 201 YSSSFSYNPQ SLGPASVSST YSPKVRSPSS SFRAGSFLSS SFRHGSINTP 251 RTRHTSISSN MTENIGPGSV PKILGGLTSD EKLRRKREFH NAVERRRREL 301 IKQKIKELGQ LVPPSLLNYD DLGKQIKPNK GIILDRTVEY LQYLAEILEI 351 QARKKKALLA KIKELEEKKS SVAALSPFTN NHHASSGQNN SENSEERIID 401 IRSVPNALMN EQNSKAELHN WEPPLYDSVG NHNHAGTMES HPHTNIHEEL 451 KEFLSGDLIE AEDNAKLMFG DDNSNPADYL LEFGSG*

Amino Acid Sequence (or in FASTA format)

       1  MMNNNESEAE NQRLLDELMN QTKVLQETLD FSLVTPTPHH NDDYKIHGSA
      51  YPGGETPAQQ HEKLSYINTH NSNDNNNLMG SQARSNSQTP TASTIYEEAE
     101  SQSSYLDDMF RTSQGGRPVT QNSISSIGQG PLRSSYSMAY DSPVDRAMNT
     151  PLQQQEGLKA ELPHDFLFQH GTDDTMYNLT DDLSSSLSSS INSDMMTPNT
     201  YSSSFSYNPQ SLGPASVSST YSPKVRSPSS SFRAGSFLSS SFRHGSINTP
     251  RTRHTSISSN MTENIGPGSV PKILGGLTSD EKLRRKREFH NAVERRRREL
     301  IKQKIKELGQ LVPPSLLNYD DLGKQIKPNK GIILDRTVEY LQYLAEILEI
     351  QARKKKALLA KIKELEEKKS SVAALSPFTN NHHASSGQNN SENSEERIID
     401  IRSVPNALMN EQNSKAELHN WEPPLYDSVG NHNHAGTMES HPHTNIHEEL
     451  KEFLSGDLIE AEDNAKLMFG DDNSNPADYL LEFGSG*

external links for Rtg3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rtg3p

1)	Jia Y, et al. (1997) A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17(3):1110-7
2)	Rothermel BA, et al. (1997) Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem 272(32):19801-7
3)	Crespo JL, et al. (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A 99(10):6784-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41