ATP1/YBL099W Protein Information

Standard Name	Atp1p
Systematic Name	Ybl099wp
ORF Classification	Verified
Description	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated (1, 2)
Name Description	ATP synthase

Experimental Data
Molecules/cell	41500 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	545
Molecular Weight (Da)	58,608
Isoelectric Point (pI)	9.5

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atp1p (InterPro)
Physical Interactions	There are 54 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001688DB \| P07251 MIPS: YBL099W NCBI: 119389904 \| 119389905 \| 119389906 \| 119389913 \| 119389914 \| 119389915 \| 119389922 \| 119389923 \| 119389924 \| 1660995 \| 171116 \| 224510808 \| 224510809 \| 224510810 \| 224510817 \| 224510818 \| 224510819 \| 224510826 \| 224510827 \| 224510828 \| 2447011 \| 300193115 \| 300193116 \| 300193117 \| 306991949 \| 306991950 \| 306991951 \| 306991958 \| 306991959 \| 306991960 \| 306991967 \| 306991968 \| 306991969 \| 306991976 \| 306991977 \| 306991978 \| 306991985 \| 306991986 \| 306991987 \| 306991994 \| 306991995 \| 306991996 \| 306992003 \| 306992004 \| 306992005 \| 306992012 \| 306992013 \| 306992014 \| 306992021 \| 306992022 \| 306992023 \| 306992030 \| 306992031 \| 306992032 \| 306992039 \| 306992040 \| 306992041 \| 306992048 \| 306992049 \| 306992050 \| 307568098 \| 307568099 \| 307568100 \| 330443397 \| 341940649 \| 372467205 \| 372467206 \| 372467207 \| 402550241 \| 402550242 \| 402550243 \| 449802270 \| 449802271 \| 449802272 \| 449802280 \| 449802281 \| 449802282 \| 51013389 \| 56404985 \| NP_009453.2 GenBank/EMBL/DDBJ: DAA07026.2 \| AY692969 \| D37948 \| D88458 \| J02603 \| X79489 \| Z35861
External Classifications	EC: 3.6.3.14 [H(+)-transporting two-sector ATPase]

Amino Acid Sequence (or in FASTA format)
1 MLARTAAIRS LSRTLINSTK AARPAAAALA STRRLASTKA QPTEVSSILE 51 ERIKGVSDEA NLNETGRVLA VGDGIARVFG LNNIQAEELV EFSSGVKGMA 101 LNLEPGQVGI VLFGSDRLVK EGELVKRTGN IVDVPVGPGL LGRVVDALGN 151 PIDGKGPIDA AGRSRAQVKA PGILPRRSVH EPVQTGLKAV DALVPIGRGQ 201 RELIIGDRQT GKTAVALDTI LNQKRWNNGS DESKKLYCVY VAVGQKRSTV 251 AQLVQTLEQH DAMKYSIIVA ATASEAAPLQ YLAPFTAASI GEWFRDNGKH 301 ALIVYDDLSK QAVAYRQLSL LLRRPPGREA YPGDVFYLHS RLLERAAKLS 351 EKEGSGSLTA LPVIETQGGD VSAYIPTNVI SITDGQIFLE AELFYKGIRP 401 AINVGLSVSR VGSAAQVKAL KQVAGSLKLF LAQYREVAAF AQFGSDLDAS 451 TKQTLVRGER LTQLLKQNQY SPLATEEQVP LIYAGVNGHL DGIELSRIGE 501 FESSFLSYLK SNHNELLTEI REKGELSKEL LASLKSATES FVATF*

Amino Acid Sequence (or in FASTA format)

       1  MLARTAAIRS LSRTLINSTK AARPAAAALA STRRLASTKA QPTEVSSILE
      51  ERIKGVSDEA NLNETGRVLA VGDGIARVFG LNNIQAEELV EFSSGVKGMA
     101  LNLEPGQVGI VLFGSDRLVK EGELVKRTGN IVDVPVGPGL LGRVVDALGN
     151  PIDGKGPIDA AGRSRAQVKA PGILPRRSVH EPVQTGLKAV DALVPIGRGQ
     201  RELIIGDRQT GKTAVALDTI LNQKRWNNGS DESKKLYCVY VAVGQKRSTV
     251  AQLVQTLEQH DAMKYSIIVA ATASEAAPLQ YLAPFTAASI GEWFRDNGKH
     301  ALIVYDDLSK QAVAYRQLSL LLRRPPGREA YPGDVFYLHS RLLERAAKLS
     351  EKEGSGSLTA LPVIETQGGD VSAYIPTNVI SITDGQIFLE AELFYKGIRP
     401  AINVGLSVSR VGSAAQVKAL KQVAGSLKLF LAQYREVAAF AQFGSDLDAS
     451  TKQTLVRGER LTQLLKQNQY SPLATEEQVP LIYAGVNGHL DGIELSRIGE
     501  FESSFLSYLK SNHNELLTEI REKGELSKEL LASLKSATES FVATF*

external links for Atp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Atp1p

1)	Takeda M, et al. (1986) Nuclear genes encoding the yeast mitochondrial ATPase complex. Analysis of ATP1 coding the F1-ATPase alpha-subunit and its assembly. J Biol Chem 261(32):15126-33
2)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41