ROX3/YBL093C Protein Information Help

Standard Name Rox3p
Systematic Name Ybl093cp
Alias Nut3p 1 , Ssn7p , Med19p 2 , Ssx2p 3
ORF Classification Verified
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme (4, 5)
Name Description Repressor Of hypoXic genes
Experimental Data
Molecules/cell 6120 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 220
Molecular Weight (Da) 24,857
Isoelectric Point (pI) 6.29

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rox3p (InterPro)
Physical Interactions There are 89 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053159 | P25046
MIPS: YBL093C
NCBI: 1870089 | 2507116 | 4364 | 45270474 | 496682 | 6319377 | NP_009459.1 | NM_001178333.1
GenBank/EMBL/DDBJ: AAS56618.1 | CAA41233.1 | CAA56009.1 | CAA84915.1 | DAA07030.1 | AY558292 | X58300 | X79489 | Z35854
Amino Acid Sequence (or in FASTA format)
       1  MASRVDETTV PSYYYYVDPE TTYTYQQPNP LQDLISVYGL DDISRQVART
      51  NLDGTKAVKL RKSYKNQIAD LSGKFSTIPT RENGKGGQIA HILFQNNPDM
     101  MIQPPQQGQN MSEQQWREQL RNRDIALFQP PNFDWDLCSS VLSQFERSYP
     151  SEFANQNQGG AQAPFDIDDL AFDLDGTGKS QSGSNSGNNS KKRKNKSSGS
     201  SMATPTHSDS HEDMKRRRLE *                               

external links for Rox3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rox3p
1) Tabtiang RK and Herskowitz I  (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol 18(8):4707-18
2) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
3) Li L, et al.  (2005) Genetic interactions between mediator and the late G1-specific transcription factor Swi6 in Saccharomyces cerevisiae. Genetics 171(2):477-88
4) Gustafsson CM, et al.  (1997) Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. J Biol Chem 272(1):48-50
5) Myers LC, et al.  (1998) The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev 12(1):45-54
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41