ROX3/YBL093C Protein Information

Standard Name	Rox3p
Systematic Name	Ybl093cp
Alias	Nut3p 1 , Ssn7p , Med19p 2
ORF Classification	Verified
Description	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme (3, 4)
Name Description	Repressor Of hypoXic genes

Experimental Data
Molecules/cell	6120 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	220
Molecular Weight (Da)	24,857
Isoelectric Point (pI)	6.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rox3p (InterPro)
Physical Interactions	There are 89 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053159 \| P25046 MIPS: YBL093C NCBI: 1870089 \| 2507116 \| 4364 \| 45270474 \| 496682 \| 6319377 \| NP_009459.1 GenBank/EMBL/DDBJ: DAA07030.1 \| AY558292 \| X58300 \| X79489 \| Z35854

Amino Acid Sequence (or in FASTA format)
1 MASRVDETTV PSYYYYVDPE TTYTYQQPNP LQDLISVYGL DDISRQVART 51 NLDGTKAVKL RKSYKNQIAD LSGKFSTIPT RENGKGGQIA HILFQNNPDM 101 MIQPPQQGQN MSEQQWREQL RNRDIALFQP PNFDWDLCSS VLSQFERSYP 151 SEFANQNQGG AQAPFDIDDL AFDLDGTGKS QSGSNSGNNS KKRKNKSSGS 201 SMATPTHSDS HEDMKRRRLE *

Amino Acid Sequence (or in FASTA format)

       1  MASRVDETTV PSYYYYVDPE TTYTYQQPNP LQDLISVYGL DDISRQVART
      51  NLDGTKAVKL RKSYKNQIAD LSGKFSTIPT RENGKGGQIA HILFQNNPDM
     101  MIQPPQQGQN MSEQQWREQL RNRDIALFQP PNFDWDLCSS VLSQFERSYP
     151  SEFANQNQGG AQAPFDIDDL AFDLDGTGKS QSGSNSGNNS KKRKNKSSGS
     201  SMATPTHSDS HEDMKRRRLE *

external links for Rox3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rox3p

1)	Tabtiang RK and Herskowitz I (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol 18(8):4707-18
2)	Bourbon HM, et al. (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
3)	Gustafsson CM, et al. (1997) Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. J Biol Chem 272(1):48-50
4)	Myers LC, et al. (1998) The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev 12(1):45-54
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41