TEL1/YBL088C Protein Information

Standard Name	Tel1p 1
Systematic Name	Ybl088cp
ORF Classification	Verified
Description	Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) (2, 3, 4, 5, 6)
Name Description	TELomere maintenance 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	2,787
Molecular Weight (Da)	321,524
Isoelectric Point (pI)	6.92

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tel1p (InterPro)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD2C \| P38110 MIPS: YBL088C NCBI: 1870083 \| 330443403 \| 341940587 \| 496689 \| 586447 \| 896461 \| NP_009465.2 GenBank/EMBL/DDBJ: DAA07036.2 \| U31331 \| X79489 \| Z35849
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MEDHGIVETL NFLSSTKIKE RNNALDELTT ILKEDPERIP TKALSTTAEA 51 LVELLASEHT KYCDLLRNLT VSTTNKLSLS ENRLSTISYV LRLFVEKSCE 101 RFKVKTLKLL LAVVPELMVK DGSKSLLDAV SVHLSFALDA LIKSDPFKLK 151 FMIHQWISLV DKICEYFQSQ MKLSMVDKTL TNFISILLNL LALDTVGIFQ 201 VTRTITWTVI DFLRLSKKEN GNTRLIMSLI NQLILKCHCF SVIDTLMLIK 251 EAWSYNLTIG CTSNELVQDQ LSLFDVMSSE LMNHKLPYMI GQENYVEELR 301 SESLVSLYRE YILLRLSNYK PQLFTVNHVE FSYIRGSRDK NSWFALPDFR 351 LRDRGGRSVW LKILGITKSL LTYFALNRKN ENYSLLFKRR KCDSDIPSIL 401 RISDDMDTFL IHLLEENSSH EFEVLGLQLC SFYGTLQDFT KSFAEQLKEL 451 LFSKFEKIQC FNWVCFSFIP LLSQKECELS NGDMARLFKV CLPLVKSNES 501 CQLSCLLLAN SIKFSKQLLS DEKTINQIYD LYELSDILGP ILVTNESFML 551 WGYLQYVGKD FQSMNGISSA DRIFEWLKSK WNQLRGTDAK QDQFCNFISW 601 LGNKYDPENP FNDKKGEGAN PVSLCWDESH KIWQHFQEQR EFLLGVKPEE 651 KSECFNTPFF NLPKVSLDLT RYNEILYRLL ENIESDAFSS PLQKFTWVAK 701 LIQIVDNLCG DSTFSEFIAA YKRTTLITIP QLSFDSQNSY QSFFEEVLSI 751 RTINVDHLVL DKINMKEIVN DFIRMQKNKS QTGTSAINYF EASSEDTTQN 801 NSPYTIGGRF QKPLHSTIDK AVRAYLWSSR NKSISERLVA ILEFSDCVST 851 DVFISYLGTV CQWLKQAIGE KSSYNKILEE FTEVLGEKLL CNHYSSSNQA 901 MLLLTSYIEA IRPQWLSYPE QPLNSDCNDI LDWIISRFED NSFTGVAPTV 951 NLSMLLLSLL QNHDLSHGSI RGGKQRVFAT FIKCLQKLDS SNIINIMNSI 1001 SSYMAQVSYK NQSIIFYEIK SLFGPPQQSI EKSAFYSLAM SMLSLVSYPS 1051 LVFSLEDMMT YSGFNHTRAF IQQALNKITV AFRYQNLTEL FEYCKFDLIM 1101 YWFNRTKVPT SKLEKEWDIS LFGFADIHEF LGRYFVEISA IYFSQGFNQK 1151 WILDMLHAIT GNGDAYLVDN SYYLCIPLAF ISGGVNELIF DILPQISGKT 1201 TVKYHKKYRL LMLKWIIRFT DLGSLTELRS TVEKLFPTSY LSPYLFENSS 1251 VSMRYQYPLH IPLALGATLV QTQFAHEKNN THEFKLLFLS VITDLEKTST 1301 YIGKLRCARE LKYLFVLYEN VLVKSSTLNF IIIRLSKFLI DTQIHDEVIT 1351 IFSSLLNLAD KNTFEIEPSL PNLFCKIFIY LRENKQLSPS FQQAIKLLEH 1401 RDLIKIKTWK YCLDAIFGNI VQDDIYENTE LLDASDCGVD DVVLVSLLFS 1451 YARRPVASKI GCSLSKAAAI NILKHHVPKE YLSKNFKLWF AALSRRILQQ 1501 EVQRERSTNF NNEVHLKNFE MVFRHPEQPH MIYQRISTFN KEAELYDSTE 1551 VFFISECILT YLVGYSIGNS ESEFCFRDNI MNENKDKVAP LDKDVLNAIY 1601 PLANNFGMES FICDTYLSVN EPYNCWLSKF ARSLIHQISF NIPPIVCLYP 1651 LCKGSTAFCE LVLTDLFFLS TTYDPKSCLN WSNRIFTQIA MLLHVKDSEI 1701 KLKMLFNVIK MIRMGSRCKE RNCLRIYSSL DLQEICQISL KIKEFKFGYL 1751 LFEEMNMPNI REMNINTLQK IYECINDGDF LAGLPVPHSI EGVLNSINRI 1801 DSDTWKRFLF NNADFDANYT TSLEEEKESL IKATEDSGFY GLTSLLESRL 1851 SGSSDVYKWN LELGDWKLLT PKVVDSKAKG LYYAIKNLPQ DVGFAEKSLE 1901 KSLLTIFDSR QHFISQTEWM DTLNAIIEFI KIAAIPQDVT SFPQTLMSIM 1951 KADKERLNTI DFYDHKTTLK SRHTLMNVLS RNSLDENVKC SKYLRLGSII 2001 QLANYVQLAI ANGAPQDALR NATLMSKTVK NIAKLYDDPS VVSQIEKLAS 2051 FTSANALWES REYKAPVMIM RDLLAQNEKN ISESILYDDF KLLINVPMDQ 2101 IKARLVKWSS ESRLEPAAAI YEKIIVNWDI NVEDHESCSD VFYTLGSFLD 2151 EQAQKLRSNG EIEDREHRSY TGKSTLKALE LIYKNTKLPE NERKDAKRHY 2201 NRVLLQYNRD SEVLKALLLQ KEKFLWHALH FYLNTLVFSN RYDNDIIDKF 2251 CGLWFENDDN SKINQLLYKE IGTIPSWKFL PWVNQIASKI SMEENEFQKP 2301 LQLTMKRLLY KLPYDSLYSV MSILLYEKQS NKDTNISQKI QAVKKILLEL 2351 QGYDRGAFAK KYLLPVQEFC EMSVELANLK FVQNTKTLRL ANLKIGQYWL 2401 KQLNMEKLPL PTSNFTVKSS ADGRKARPYI VSVNETVGIT TTGLSLPKIV 2451 TFNISDGTTQ KALMKGSNDD LRQDAIMEQV FQQVNKVLQN DKVLRNLDLG 2501 IRTYKVVPLG PKAGIIEFVA NSTSLHQILS KLHTNDKITF DQARKGMKAV 2551 QTKSNEERLK AYLKITNEIK PQLRNFFFDS FPDPLDWFEA KKTYTKGVAA 2601 SSIVGYILGL GDRHLNNILL DCSTGEPIHI DLGIAFDQGK LLPIPELVPF 2651 RLTRDIVDGF GVTGVDGLFR RSCERVYAVL RKDYVKVMCV LNILKWDPLY 2701 SWVMSPVKKY EHLFEEEHEI TNFDNVSKFI SNNDRNENQE SYRALKGVEE 2751 KLMGNGLSVE SSVQDLIQQA TDPSNLSVIY MGWSPFY*

Amino Acid Sequence (or in FASTA format)

       1  MEDHGIVETL NFLSSTKIKE RNNALDELTT ILKEDPERIP TKALSTTAEA
      51  LVELLASEHT KYCDLLRNLT VSTTNKLSLS ENRLSTISYV LRLFVEKSCE
     101  RFKVKTLKLL LAVVPELMVK DGSKSLLDAV SVHLSFALDA LIKSDPFKLK
     151  FMIHQWISLV DKICEYFQSQ MKLSMVDKTL TNFISILLNL LALDTVGIFQ
     201  VTRTITWTVI DFLRLSKKEN GNTRLIMSLI NQLILKCHCF SVIDTLMLIK
     251  EAWSYNLTIG CTSNELVQDQ LSLFDVMSSE LMNHKLPYMI GQENYVEELR
     301  SESLVSLYRE YILLRLSNYK PQLFTVNHVE FSYIRGSRDK NSWFALPDFR
     351  LRDRGGRSVW LKILGITKSL LTYFALNRKN ENYSLLFKRR KCDSDIPSIL
     401  RISDDMDTFL IHLLEENSSH EFEVLGLQLC SFYGTLQDFT KSFAEQLKEL
     451  LFSKFEKIQC FNWVCFSFIP LLSQKECELS NGDMARLFKV CLPLVKSNES
     501  CQLSCLLLAN SIKFSKQLLS DEKTINQIYD LYELSDILGP ILVTNESFML
     551  WGYLQYVGKD FQSMNGISSA DRIFEWLKSK WNQLRGTDAK QDQFCNFISW
     601  LGNKYDPENP FNDKKGEGAN PVSLCWDESH KIWQHFQEQR EFLLGVKPEE
     651  KSECFNTPFF NLPKVSLDLT RYNEILYRLL ENIESDAFSS PLQKFTWVAK
     701  LIQIVDNLCG DSTFSEFIAA YKRTTLITIP QLSFDSQNSY QSFFEEVLSI
     751  RTINVDHLVL DKINMKEIVN DFIRMQKNKS QTGTSAINYF EASSEDTTQN
     801  NSPYTIGGRF QKPLHSTIDK AVRAYLWSSR NKSISERLVA ILEFSDCVST
     851  DVFISYLGTV CQWLKQAIGE KSSYNKILEE FTEVLGEKLL CNHYSSSNQA
     901  MLLLTSYIEA IRPQWLSYPE QPLNSDCNDI LDWIISRFED NSFTGVAPTV
     951  NLSMLLLSLL QNHDLSHGSI RGGKQRVFAT FIKCLQKLDS SNIINIMNSI
    1001  SSYMAQVSYK NQSIIFYEIK SLFGPPQQSI EKSAFYSLAM SMLSLVSYPS
    1051  LVFSLEDMMT YSGFNHTRAF IQQALNKITV AFRYQNLTEL FEYCKFDLIM
    1101  YWFNRTKVPT SKLEKEWDIS LFGFADIHEF LGRYFVEISA IYFSQGFNQK
    1151  WILDMLHAIT GNGDAYLVDN SYYLCIPLAF ISGGVNELIF DILPQISGKT
    1201  TVKYHKKYRL LMLKWIIRFT DLGSLTELRS TVEKLFPTSY LSPYLFENSS
    1251  VSMRYQYPLH IPLALGATLV QTQFAHEKNN THEFKLLFLS VITDLEKTST
    1301  YIGKLRCARE LKYLFVLYEN VLVKSSTLNF IIIRLSKFLI DTQIHDEVIT
    1351  IFSSLLNLAD KNTFEIEPSL PNLFCKIFIY LRENKQLSPS FQQAIKLLEH
    1401  RDLIKIKTWK YCLDAIFGNI VQDDIYENTE LLDASDCGVD DVVLVSLLFS
    1451  YARRPVASKI GCSLSKAAAI NILKHHVPKE YLSKNFKLWF AALSRRILQQ
    1501  EVQRERSTNF NNEVHLKNFE MVFRHPEQPH MIYQRISTFN KEAELYDSTE
    1551  VFFISECILT YLVGYSIGNS ESEFCFRDNI MNENKDKVAP LDKDVLNAIY
    1601  PLANNFGMES FICDTYLSVN EPYNCWLSKF ARSLIHQISF NIPPIVCLYP
    1651  LCKGSTAFCE LVLTDLFFLS TTYDPKSCLN WSNRIFTQIA MLLHVKDSEI
    1701  KLKMLFNVIK MIRMGSRCKE RNCLRIYSSL DLQEICQISL KIKEFKFGYL
    1751  LFEEMNMPNI REMNINTLQK IYECINDGDF LAGLPVPHSI EGVLNSINRI
    1801  DSDTWKRFLF NNADFDANYT TSLEEEKESL IKATEDSGFY GLTSLLESRL
    1851  SGSSDVYKWN LELGDWKLLT PKVVDSKAKG LYYAIKNLPQ DVGFAEKSLE
    1901  KSLLTIFDSR QHFISQTEWM DTLNAIIEFI KIAAIPQDVT SFPQTLMSIM
    1951  KADKERLNTI DFYDHKTTLK SRHTLMNVLS RNSLDENVKC SKYLRLGSII
    2001  QLANYVQLAI ANGAPQDALR NATLMSKTVK NIAKLYDDPS VVSQIEKLAS
    2051  FTSANALWES REYKAPVMIM RDLLAQNEKN ISESILYDDF KLLINVPMDQ
    2101  IKARLVKWSS ESRLEPAAAI YEKIIVNWDI NVEDHESCSD VFYTLGSFLD
    2151  EQAQKLRSNG EIEDREHRSY TGKSTLKALE LIYKNTKLPE NERKDAKRHY
    2201  NRVLLQYNRD SEVLKALLLQ KEKFLWHALH FYLNTLVFSN RYDNDIIDKF
    2251  CGLWFENDDN SKINQLLYKE IGTIPSWKFL PWVNQIASKI SMEENEFQKP
    2301  LQLTMKRLLY KLPYDSLYSV MSILLYEKQS NKDTNISQKI QAVKKILLEL
    2351  QGYDRGAFAK KYLLPVQEFC EMSVELANLK FVQNTKTLRL ANLKIGQYWL
    2401  KQLNMEKLPL PTSNFTVKSS ADGRKARPYI VSVNETVGIT TTGLSLPKIV
    2451  TFNISDGTTQ KALMKGSNDD LRQDAIMEQV FQQVNKVLQN DKVLRNLDLG
    2501  IRTYKVVPLG PKAGIIEFVA NSTSLHQILS KLHTNDKITF DQARKGMKAV
    2551  QTKSNEERLK AYLKITNEIK PQLRNFFFDS FPDPLDWFEA KKTYTKGVAA
    2601  SSIVGYILGL GDRHLNNILL DCSTGEPIHI DLGIAFDQGK LLPIPELVPF
    2651  RLTRDIVDGF GVTGVDGLFR RSCERVYAVL RKDYVKVMCV LNILKWDPLY
    2701  SWVMSPVKKY EHLFEEEHEI TNFDNVSKFI SNNDRNENQE SYRALKGVEE
    2751  KLMGNGLSVE SSVQDLIQQA TDPSNLSVIY MGWSPFY*

external links for Tel1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Tel1p

1)	Lustig AJ and Petes TD (1986) Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A 83(5):1398-402
2)	Ritchie KB and Petes TD (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9
3)	Craven RJ, et al. (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507
4)	Giannattasio M, et al. (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
5)	Nakada D, et al. (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24
6)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76