SKT5/YBL061C Protein Information Help

Standard Name Skt5p
Systematic Name Ybl061cp
Alias Cal2p , Chs4p , Csd4p
ORF Classification Verified
Description Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Experimental Data
Molecules/cell 2580 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 696
Molecular Weight (Da) 77,066
Isoelectric Point (pI) 10.08

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Skt5p (InterPro)
Physical Interactions There are 33 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001359E8 | P34226
MIPS: YBL061C
NCBI: 313737 | 415510 | 465520 | 536097 | 6319410 | NP_009492.1 | NM_001178301.1
GenBank/EMBL/DDBJ: DAA07058.1 | S65415 | Z23261 | Z35823
Amino Acid Sequence (or in FASTA format)
 
       1  MASSPQVHPY KKHLMQSQHI NFDNRGLQFQ NSSLKVGQDF SDNKENRENR
      51  DNEDFSTADL PKRSANQPLI NEHLRAASVP LLSNDIGNSQ EEDFVPVPPP
     101  QLHLNNSNNT SLSSLGSTPT NSPSPGALRQ TNSSTSLTKE QIKKRTRSVD
     151  LSHMYLLNGS SDTQLTATNE SVADLSHQMI SRYLGGKNNT SLVPRLKTIE
     201  MYRQNVKKSK DPEVLFQYAQ YMLQTALTIE SSNALVQDSD KEGNVSQSDL
     251  KLQFLKEAQS YLKKLSIKGY SDAQYLLADG YSSGAFGKIE NKEAFVLFQA
     301  AAKHGHIESA YRASHCLEEG LGTTRDSRKS VNFLKFAASR NHPSAMYKLG
     351  LYSFYGRMGL PTDVNTKLNG VKWLSRAAAR ANELTAAAPY ELAKIYHEGF
     401  LDVVIPDEKY AMELYIQAAS LGHVPSATLL AQIYETGNDT VGQDTSLSVH
     451  YYTQAALKGD SVAMLGLCAW YLLGAEPAFE KDENEAFQWA LRAANAGLPK
     501  AQFTLGYFYE HGKGCDRNME YAWKWYEKAA GNEDKRAINK LRSRDGGLAS
     551  IGKKQHKKNK SISTLNLFST VDSQTSNVGS NSRVSSKSET FFTGNPKRDR
     601  EPQGLQINMN SNTNRNGIKT GSDTSIRKSS SSAKGMSREV AEQSMAAKQE
     651  VSLSNMGSSN MIRKDFPAVK TESKKPTSLK NKKDKQGKKK KDCVIM*

external links for Skt5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Skt5p
1) Ono N, et al.  (2000) The yeast Chs4 protein stimulates the trypsin-sensitive activity of chitin synthase 3 through an apparent protein-protein interaction. Microbiology 146 ( Pt 2):385-91
2) Trilla JA, et al.  (1997) Characterization of CHS4 (CAL2), a gene of Saccharomyces cerevisiae involved in chitin biosynthesis and allelic to SKT5 and CSD4. Yeast 13(9):795-807
3) Sanz M, et al.  (2002) Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation. Mol Microbiol 43(5):1183-95
4) Kozubowski L, et al.  (2003) A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Mol Biol Cell 14(1):26-39
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41