SHP1/YBL058W Protein Information

Standard Name	Shp1p
Systematic Name	Ybl058wp
Alias	Ubx1p 1
ORF Classification	Verified
Description	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate (1, 2, 3)
Name Description	Suppressor of High-copy PP1 2

Experimental Data
Molecules/cell	3200 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	423
Molecular Weight (Da)	46,987
Isoelectric Point (pI)	4.72

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Shp1p (InterPro)
Physical Interactions	There are 66 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F8CD \| P34223 MIPS: YBL058W NCBI: 313740 \| 45269325 \| 465517 \| 536090 \| 6319413 \| NP_009495.1 GenBank/EMBL/DDBJ: DAA07062.1 \| AY557717 \| Z23261 \| Z35819

Amino Acid Sequence (or in FASTA format)
1 MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD 51 RREEAHWNRQ QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY 101 LKRKGSTSPE PTKGSSRSGS GNNSRFMSFS DMVRGQADDD DEDQPRNTFA 151 GGETSGLEVT DPSDPNSLLK DLLEKARRGG QMGAENGFRD DEDHEMGANR 201 FTGRGFRLGS TIDAADEVVE DNTSQSQRRP EKVTREITFW KEGFQVADGP 251 LYRYDDPANS FYLSELNQGR APLKLLDVQF GQEVEVNVYK KLDESYKAPT 301 RKLGGFSGQG QRLGSPIPGE SSPAEVPKNE TPAAQEQPMP DNEPKQGDTS 351 IQIRYANGKR EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP 401 ISNDETTLKD ADLLNSVVVQ RWA*

Amino Acid Sequence (or in FASTA format)

       1  MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD
      51  RREEAHWNRQ QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY
     101  LKRKGSTSPE PTKGSSRSGS GNNSRFMSFS DMVRGQADDD DEDQPRNTFA
     151  GGETSGLEVT DPSDPNSLLK DLLEKARRGG QMGAENGFRD DEDHEMGANR
     201  FTGRGFRLGS TIDAADEVVE DNTSQSQRRP EKVTREITFW KEGFQVADGP
     251  LYRYDDPANS FYLSELNQGR APLKLLDVQF GQEVEVNVYK KLDESYKAPT
     301  RKLGGFSGQG QRLGSPIPGE SSPAEVPKNE TPAAQEQPMP DNEPKQGDTS
     351  IQIRYANGKR EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP
     401  ISNDETTLKD ADLLNSVVVQ RWA*

external links for Shp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Shp1p

1)	Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24
2)	Zhang S, et al. (1995) The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression. Mol Cell Biol 15(4):2037-50
3)	Tong AH, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303(5659):808-13
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41