SAS3/YBL052C Protein Information Help

Standard Name Sas3p 1
Systematic Name Ybl052cp
ORF Classification Verified
Description Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal (1, 2, 3, 4)
Name Description Something About Silencing 5
Gene Product KAT6 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 831
Molecular Weight (Da) 97,582
Isoelectric Point (pI) 6.4

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sas3p (InterPro)
Physical Interactions There are 28 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000135570 | P34218
MIPS: YBL052C
NCBI: 313745 | 465512 | 536080 | 6319419 | NP_009501.1
GenBank/EMBL/DDBJ: DAA07067.1 | Z23261 | Z35814
External Classifications EC: 2.3.1.48 [Histone acetyltransferase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSLTANDESP KPKKNALLKN LEIDDLIHSQ FVRSDTNGHR TTRRLFNSDA
      51  SISHRIRGSV RSDKGLNKIK KGLISQQSKL ASENSSQNIV NRDNKMGAVS
     101  FPIIEPNIEV SEELKVRIKY DSIKFFNFER LISKSSVIAP LVNKNITSSG
     151  PLIGFQRRVN RLKQTWDLAT ENMEYPYSSD NTPFRDNDSW QWYVPYGGTI
     201  KKMKDFSTKR TLPTWEDKIK FLTFLENSKS ATYINGNVSL CNHNETDQEN
     251  EDRKKRKGKV PRIKNKVWFS QIEYIVLRNY EIKPWYTSPF PEHINQNKMV
     301  FICEFCLKYM TSRYTFYRHQ LKCLTFKPPG NEIYRDGKLS VWEIDGRENV
     351  LYCQNLCLLA KCFINSKTLY YDVEPFIFYI LTEREDTENH PYQNAAKFHF
     401  VGYFSKEKFN SNDYNLSCIL TLPIYQRKGY GQFLMEFSYL LSRKESKFGT
     451  PEKPLSDLGL LTYRTFWKIK CAEVLLKLRD SARRRSNNKN EDTFQQVSLN
     501  DIAKLTGMIP TDVVFGLEQL QVLYRHKTRS LSSLDDFNYI IKIDSWNRIE
     551  NIYKTWSSKN YPRVKYDKLL WEPIILGPSF GINGMMNLEP TALADEALTN
     601  ETMAPVISNN THIENYNNSR AHNKRRRRRR RSSEHKTSKL HVNNIIEPEV
     651  PATDFFEDTV SSLTEYMCDY KNTNNDRLIY QAEKRVLESI HDRKGIPRSK
     701  FSTETHWELC FTIKNSETPL GNHAARRNDT GISSLEQDEV ENDVDTELYV
     751  GENAKEDEDE DEDFTLDDDI EDEQISEEND EEEDTYEEDS DDDEDGKRKG
     801  QEQDENDIES HIRKERVRKR RKITLIEDDE E*

external links for Sas3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sas3p
1) Reifsnyder C, et al.  (1996) Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14(1):42-9
2) John S, et al.  (2000) The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev 14(10):1196-208
3) Howe L, et al.  (2001) Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev 15(23):3144-54
4) Torres EM, et al.  (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83
5) Axelrod A and Rine J  (1991) A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol Cell Biol 11(2):1080-91
6) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6