APL3/YBL037W Protein Information Help

Standard Name Apl3p
Systematic Name Ybl037wp
ORF Classification Verified
Description Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport (1, 2, 3)
Name Description clathrin Adaptor Protein complex Large chain
Experimental Data
Molecules/cell 1590 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,025
Molecular Weight (Da) 115,010
Isoelectric Point (pI) 8.97

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Apl3p (InterPro)
Physical Interactions There are 33 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530AC | P38065
MIPS: YBL037W
NCBI: 463271 | 536049 | 586420 | 6319434 | NP_009516.1 | NM_001178277.1
GenBank/EMBL/DDBJ: CAA55057.1 | CAA84857.1 | DAA07082.1 | X78214 | Z35798
Amino Acid Sequence (or in FASTA format)
       1  MDRKKTLINS SVSNNNSTIK GLQLFIADLR SAQQAQEQEK RIQSEIVKIK
      51  QHFDAAKKKQ GNHDRLGGYQ RKKYVAKLAY IYITSNTTKL NEILFGLEQT
     101  VELLKSSIFS EKFIGYMTLE LLYERSEVVA KVNDEVNYQL MKDLSSSDDN
     151  FVMLALNFVG VVGELTNRLA YNDDITTGVF KILRSPTSSI YLKKKSALSF
     201  LALLKSNHSI LTEDLQRKQL WIQRILSLLD DTENYRLTLA TIPLIEFIAK
     251  YIDPSYCTRL LPQLTEILYN CVVVGTSRSS DNQFPLEYTF ANMPNPWLIT
     301  KVVSLLSILI ASPTERDSGS LLQTNNIDNE LLNKLRKCVS VAIELGTRQA
     351  QDPMERIVQN TVLFSLINFA SKLDPSDEAI SNSVTALCSL LTSKEINIRY
     401  LTLDSLVKLC SSSGKPAIDA VRYKNLDMIF HLLNTERDSS IVRKVVDLLY
     451  TFTDVENVKI IVDGLLQYIL SPKNLAEPQI KSDIAVKIAI LTEKYATDIN
     501  WFVIISLQLL SLTSNTTIND DEIWQRLCQI VVNNPSLHRI TCERLVDYLC
     551  KKQASEAIIK AAAFLLGEYS SLITDRISSA NLFTLFAEKY FSAPNVAKAM
     601  ILTTMIKLYK TSPEIGSNVI KFFQLELNSL DIELQTRSFE YLNIIQLAKV
     651  NGNTDILQIL FEPMPPFNSK SNPLLKRLGS LPASAGSTTL INTPSEASSS
     701  TPDLLSKRAN SSRSIMVPMP PPSRRNTIDD VNSKISSSED FSGKDSYYSR
     751  QILAPNWREG FTRMISHKQG VLFTSSLMKV FYRITTPDAQ QPYVFHISLA
     801  FINLTEWEIT GLSTQIIPSK TQGNPEYLIM NINTPSTATI GPHKRAEQSY
     851  EVSIRKPFDV EDSPILAIHF KCGGSTNTIN LKTAIGMTTT LISSDVNPSM
     901  HLNLAQFISR WKTLSDALGK EGEYQKSGIK LNKDFRKVET ISLEDGLLLL
     951  TQTVKRLGFD IVDQTSVRST LFVSGIIHTK SEGNFGCLMK IQYQVNGTVN
    1001  VTCKTTTAGP LAKYIVECIK NVLTK*                          

external links for Apl3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Apl3p
1) Panek HR, et al.  (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
2) Kirchhausen T  (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98
3) Yeung BG, et al.  (1999) Adaptor complex-independent clathrin function in yeast. Mol Biol Cell 10(11):3643-59
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41