LSM2/YBL026W Protein Information 
| Standard Name | Lsm2p |
|---|---|
| Systematic Name | Ybl026wp |
| Alias | Smx5p , Snp3p |
| ORF Classification | Verified |
| Description | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress (1, 2, 3, 4) |
| Name Description | Like SM |
| Experimental Data | |
|---|---|
| Molecules/cell | 2210 5 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Lsm2p (InterPro) |
| Physical Interactions | There are 203 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI00000530D1 | P38203 MIPS: YBL026W NCBI: 536027 | 586410 | 602898 | 6319445 | NP_009527.1 GenBank/EMBL/DDBJ: DAA07094.1 | X77291 | Z35787 |
external links for Lsm2p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA | ||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Lsm2p
| 1) | He W and Parker R (2000) Functions of Lsm proteins in mRNA degradation and splicing. Curr Opin Cell Biol 12(3):346-50 |
| 2) | Kufel J, et al. (2004) Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex. Mol Cell Biol 24(21):9646-57 |
| 3) | Beggs JD (2005) Lsm proteins and RNA processing. Biochem Soc Trans 33(Pt 3):433-8 |
| 4) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 5) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
