PEP1/YBL017C Protein Information 
| Standard Name | Pep1p |
|---|---|
| Systematic Name | Ybl017cp |
| Alias | Vps10p 1, 2 , Vpt1p 3 |
| ORF Classification | Verified |
| Description | Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments (4, 5, 6) |
| Name Description | carboxyPEPtidase Y-deficient 7 |
| Experimental Data | |
|---|---|
| Molecules/cell | 7210 8 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Pep1p (InterPro) |
| Transmembrane Domains | There are 1 total predicted transmembrane domains (TMHMM) |
| Signal Peptide(s) | There are 1 total predicted predicted signal peptide(s) (SignalP) |
| Physical Interactions | There are 41 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000053293 | P32319 MIPS: YBL017C NCBI: 3303 | 417462 | 497641 | 536009 | 6319454 | NP_009536.1 GenBank/EMBL/DDBJ: DAA07103.1 | U07621 | X68577 | Z35778 |
external links for Pep1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA |
References cited on this page View Complete Literature Guide for Pep1p
| 1) | Robinson JS, et al. (1988) Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8(11):4936-48 |
| 2) | Rothman JH, et al. (1989) Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J 8(7):2057-65 |
| 3) | Bankaitis VA, et al. (1986) Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci U S A 83(23):9075-9 |
| 4) | Cereghino JL, et al. (1995) The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol Biol Cell 6(9):1089-102 |
| 5) | Cooper AA and Stevens TH (1996) Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. J Cell Biol 133(3):529-41 |
| 6) | Marcusson EG, et al. (1994) The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 77(4):579-86 |
| 7) | Jones EW (1977) Proteinase mutants of Saccharomyces cerevisiae. Genetics 85(1):23-33 |
| 8) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
