ACH1/YBL015W Protein Information

Standard Name	Ach1p 1
Systematic Name	Ybl015wp
ORF Classification	Verified
Description	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth (2, 3, 4)
Name Description	Acetyl CoA Hydrolase 1

Experimental Data
Molecules/cell	4890 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	526
Molecular Weight (Da)	58,711
Isoelectric Point (pI)	6.77

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ach1p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001682B4 \| P32316 MIPS: YBL015W NCBI: 170980 \| 3305 \| 536005 \| 57015298 \| 6319456 \| NP_009538.1 GenBank/EMBL/DDBJ: DAA07105.1 \| M31036 \| X68577 \| Z35776
External Classifications	EC: 3.1.2.1 [Acetyl-CoA hydrolase]

Amino Acid Sequence (or in FASTA format)
1 MTISNLLKQR VRYAPYLKKV KEAHELIPLF KNGQYLGWSG FTGVGTPKAV 51 PEALIDHVEK NNLQGKLRFN LFVGASAGPE ENRWAEHDMI IKRAPHQVGK 101 PIAKAINQGR IEFFDKHLSM FPQDLTYGFY TRERKDNKIL DYTIIEATAI 151 KEDGSIVPGP SVGGSPEFIT VSDKVIIEVN TATPSFEGIH DIDMPVNPPF 201 RKPYPYLKVD DKCGVDSIPV DPEKVVAIVE STMRDQVPPN TPSDDMSRAI 251 AGHLVEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLA GAQFKHLTVW 301 TEVLQDSFLD LFENGSLDYA TATSVRLTEK GFDRAFANWE NFKHRLCLRS 351 QVVSNNPEMI RRLGVIAMNT PVEVDIYAHA NSTNVNGSRM LNGLGGSADF 401 LRNAKLSIMH APSARPTKVD PTGISTIVPM ASHVDQTEHD LDILVTDQGL 451 ADLRGLSPKE RAREIINKCA HPDYQALLTD YLDRAEHYAK KHNCLHEPHM 501 LKNAFKFHTN LAEKGTMKVD SWEPVD*

Amino Acid Sequence (or in FASTA format)

       1  MTISNLLKQR VRYAPYLKKV KEAHELIPLF KNGQYLGWSG FTGVGTPKAV
      51  PEALIDHVEK NNLQGKLRFN LFVGASAGPE ENRWAEHDMI IKRAPHQVGK
     101  PIAKAINQGR IEFFDKHLSM FPQDLTYGFY TRERKDNKIL DYTIIEATAI
     151  KEDGSIVPGP SVGGSPEFIT VSDKVIIEVN TATPSFEGIH DIDMPVNPPF
     201  RKPYPYLKVD DKCGVDSIPV DPEKVVAIVE STMRDQVPPN TPSDDMSRAI
     251  AGHLVEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLA GAQFKHLTVW
     301  TEVLQDSFLD LFENGSLDYA TATSVRLTEK GFDRAFANWE NFKHRLCLRS
     351  QVVSNNPEMI RRLGVIAMNT PVEVDIYAHA NSTNVNGSRM LNGLGGSADF
     401  LRNAKLSIMH APSARPTKVD PTGISTIVPM ASHVDQTEHD LDILVTDQGL
     451  ADLRGLSPKE RAREIINKCA HPDYQALLTD YLDRAEHYAK KHNCLHEPHM
     501  LKNAFKFHTN LAEKGTMKVD SWEPVD*

external links for Ach1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ach1p

1)	Lee FJ, et al. (1990) A glucose-repressible gene encodes acetyl-CoA hydrolase from Saccharomyces cerevisiae. J Biol Chem 265(13):7413-8
2)	Buu LM, et al. (2003) Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiae. J Biol Chem 278(19):17203-9
3)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
4)	Fleck CB and Brock M (2009) Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification. Fungal Genet Biol 46(6-7):473-85
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41