ALK2/YBL009W Protein Information

Standard Name	Alk2p 1
Systematic Name	Ybl009wp
ORF Classification	Verified
Description	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins (1, 2)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	676
Molecular Weight (Da)	76,372
Isoelectric Point (pI)	10.12

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Alk2p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A2A8 \| P32789 MIPS: YBL009W NCBI: 1680405 \| 418348 \| 535994 \| 6319462 \| NP_009544.1 GenBank/EMBL/DDBJ: DAA07110.1 \| S47695 \| Z35770
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MNFDAVADQQ MTDRRYFALE VAESDDADSS LNSSSMGSPA VDVGRKVYKI 51 TSHKGSAEDE SQSFFTSSDS PTSKTRPVGK TIENDDYYGK RSSTGSSLKQ 101 LFNKININDT AHSSNKENVS QSVLSENKLL SPSKRLSKQG LTKVTNSKFR 151 TPLRPISNQS TLSRDEPVKD FRSLKFRSGS DFKCWGDEKT SSHVHSSSVN 201 SVNSFTSTTS SSKWKFWKND NLLSRSLSSR SVNDQDPNFV QPKPTNSLQK 251 KSSISSFHNS IFGGGKHTEK KRNSGFIMPD HQSTKELNHK HSSSNLSFRS 301 LKHKTSHSSL NKLKVRRKGN TQELNHPIKK TCQISLPVPD QVSKDKIQLK 351 LKNSTSLASL SSEVTPINTL DYNDSILQQI LQLCDVKYIL HDLREAQSLG 401 LFTLNTRSVQ LSHNFWQTYH SDMQTSLICK KVCLGALSDL TTSNLISLHE 451 LKSLRLIQGT SGVANLLQAY VVPSNQCEND QNLILYLFFK YQGTPLSRCS 501 NIDYSQALSI FWQCSSILYV AESKFQLEHR NLTLDHILID SKGNVTLIDM 551 KCCRFLNIDN NKASYTRLDH HYFFQGRGTL QFEIYELMRS MLPQPISWAT 601 FEPRTNLLWL YHLSSSLLKM AKKAVVSGAL NREENILIEL THLLDPARKH 651 SKTIFKKELV IRTCGDLLSL KGEIMQ*

Amino Acid Sequence (or in FASTA format)

       1  MNFDAVADQQ MTDRRYFALE VAESDDADSS LNSSSMGSPA VDVGRKVYKI
      51  TSHKGSAEDE SQSFFTSSDS PTSKTRPVGK TIENDDYYGK RSSTGSSLKQ
     101  LFNKININDT AHSSNKENVS QSVLSENKLL SPSKRLSKQG LTKVTNSKFR
     151  TPLRPISNQS TLSRDEPVKD FRSLKFRSGS DFKCWGDEKT SSHVHSSSVN
     201  SVNSFTSTTS SSKWKFWKND NLLSRSLSSR SVNDQDPNFV QPKPTNSLQK
     251  KSSISSFHNS IFGGGKHTEK KRNSGFIMPD HQSTKELNHK HSSSNLSFRS
     301  LKHKTSHSSL NKLKVRRKGN TQELNHPIKK TCQISLPVPD QVSKDKIQLK
     351  LKNSTSLASL SSEVTPINTL DYNDSILQQI LQLCDVKYIL HDLREAQSLG
     401  LFTLNTRSVQ LSHNFWQTYH SDMQTSLICK KVCLGALSDL TTSNLISLHE
     451  LKSLRLIQGT SGVANLLQAY VVPSNQCEND QNLILYLFFK YQGTPLSRCS
     501  NIDYSQALSI FWQCSSILYV AESKFQLEHR NLTLDHILID SKGNVTLIDM
     551  KCCRFLNIDN NKASYTRLDH HYFFQGRGTL QFEIYELMRS MLPQPISWAT
     601  FEPRTNLLWL YHLSSSLLKM AKKAVVSGAL NREENILIEL THLLDPARKH
     651  SKTIFKKELV IRTCGDLLSL KGEIMQ*

external links for Alk2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Alk2p

1)	Nespoli A, et al. (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61