IMD1/YAR073W Protein Information

Standard Name	Imd1p 1
Systematic Name	Yar073wp
ORF Classification	Dubious
Description	Nonfunctional protein with homology to IMP dehydrogenase; blocked reading frame, located close to the telomere; not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in most strains of S. cerevisiae; YAR073W/YAR075W together have a paralog, IMD2, that arose from a segmental duplication (2, 3)
Name Description	IMP Dehydrogenase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	403
Molecular Weight (Da)	44,386
Isoelectric Point (pI)	8.2

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Imd1p (InterPro)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C1E \| P39567 MIPS: YAR073W NCBI: 456156 \| 731323 GenBank/EMBL/DDBJ: L28920
External Classifications	EC: 1.1.1.205 [IMP dehydrogenase]

Amino Acid Sequence (or in FASTA format)
1 MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD 51 FASSEVSLQT KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH 101 NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KEKYGFAGFP 151 VTADGKRNAK LVGAITSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG 201 NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS KSANTKQLLW 251 GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 301 LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA 351 VYNVCEFANQ FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR 401 ITR*

Amino Acid Sequence (or in FASTA format)

       1  MAAIRDYKTA LDLTKSLPRP DGLSVQELMD SKIRGGLAYN DFLILPGLVD
      51  FASSEVSLQT KLTRNITLNI PLVSSPMDTV TESEMATFMA LLDGIGFIHH
     101  NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KEKYGFAGFP
     151  VTADGKRNAK LVGAITSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG
     201  NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQKYPLAS KSANTKQLLW
     251  GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFQLNM IKWIKETFPD
     301  LEIIAGNVVT KEQAANLIAA GADGLRIGMG TGSICITQKV MACGRPQGTA
     351  VYNVCEFANQ FGVPCMADGG VQKHWSYYYQ SFGSWFFYCY DGWYVGRYYR
     401  ITR*

external links for Imd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
Ashbya (AGD)	BioGRID	SCOP Superfamily	YPL+
YGOB	BOND	GPMdb (Mass Spec.)	YeastGFP
YOGY	BioPIXIE	MIPS
	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Imd1p

1)	Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2)	Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8
3)	Katju V, et al. (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75