KIN3/YAR018C Protein Information

Standard Name	Kin3p
Systematic Name	Yar018cp
Alias	Fun52p 1 , Npk1p
ORF Classification	Verified
Description	Nonessential serine/threonine protein kinase; possible role in DNA damage response (2, 3)
Name Description	protein KINase

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	435
Molecular Weight (Da)	51,203
Isoelectric Point (pI)	8.65

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Kin3p (InterPro)
Physical Interactions	There are 125 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005311D \| P22209 MIPS: YAR018C NCBI: 125412 \| 171791 \| 298026 \| 349756 \| 6319327 \| 7544603 \| NP_009410.1 GenBank/EMBL/DDBJ: DAA06995.1 \| L22015 \| M55416 \| M67445 \| X60549
External Classifications	EC: 2.7.1.- [Phosphotransferases with an alcohol group as acceptor] EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL 51 LVRKDIKYGH MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY 101 LYMEYCSRGD LSQMIKHYKQ EHKYIPEKIV WGILAQLLTA LYKCHYGVEL 151 PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI FLSYDDSDYN INEQVDGHEE 201 VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET SIQFATTYVG 251 TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI 301 KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL 351 QLERFERKLL DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR 401 EVISGKKVGK VPESINGYYG KKFAKPAYHW QTRYR*

Amino Acid Sequence (or in FASTA format)

       1  MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL
      51  LVRKDIKYGH MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY
     101  LYMEYCSRGD LSQMIKHYKQ EHKYIPEKIV WGILAQLLTA LYKCHYGVEL
     151  PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI FLSYDDSDYN INEQVDGHEE
     201  VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET SIQFATTYVG
     251  TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI
     301  KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL
     351  QLERFERKLL DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR
     401  EVISGKKVGK VPESINGYYG KKFAKPAYHW QTRYR*

external links for Kin3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Kin3p

1)	Barton AB, et al. (1992) Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases. Gene 117(1):137-40
2)	Jones DG and Rosamond J (1990) Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing. Gene 90(1):87-92
3)	Moura DJ, et al. (2010) Kin3 protein, a NIMA-related kinase of Saccharomyces cerevisiae, is involved in DNA adduct damage response. Cell Cycle 9(11):2220-9