SWD1/YAR003W Protein Information

Standard Name	Swd1p 1
Systematic Name	Yar003wp
Alias	Fun16p 2 , Cps50p 3 , Saf49p 4
ORF Classification	Verified
Description	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 (1, 3, 4, 5, 6, 7)
Name Description	Set1c, WD40 repeat protein

Experimental Data
Molecules/cell	907 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	426
Molecular Weight (Da)	48,654
Isoelectric Point (pI)	4.52

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Swd1p (InterPro)
Physical Interactions	There are 76 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FF1 \| P39706 MIPS: YAR003W NCBI: 349751 \| 6319320 \| 731300 \| NP_009403.1 GenBank/EMBL/DDBJ: DAA06988.1 \| L22015

Amino Acid Sequence (or in FASTA format)
1 MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL 51 VIYDMDTFRP ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD 101 LSKPSKPLKE IRFDSPIWGC QWLDAKRRLC VATIFEESDA YVIDFSNDPV 151 ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH PNIIIVGTSK GWLDFYKFHS 201 LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ YEISIDDENS 251 AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT 301 SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA 351 LAPDFEEVEE NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD 401 VRGNNLLVER FTIPTDYTRI IKMQSS*

Amino Acid Sequence (or in FASTA format)

       1  MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL
      51  VIYDMDTFRP ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD
     101  LSKPSKPLKE IRFDSPIWGC QWLDAKRRLC VATIFEESDA YVIDFSNDPV
     151  ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH PNIIIVGTSK GWLDFYKFHS
     201  LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ YEISIDDENS
     251  AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT
     301  SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA
     351  LAPDFEEVEE NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD
     401  VRGNNLLVER FTIPTDYTRI IKMQSS*

external links for Swd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Swd1p

1)	Roguev A, et al. (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
2)	Steensma HY, et al. (1987) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and analysis of the CEN1-ADE1-CDC15 region. Mol Cell Biol 7(1):410-9
3)	Miller T, et al. (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
4)	Nagy PL, et al. (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
5)	Krogan NJ, et al. (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
6)	Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
7)	Cheng H, et al. (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41