GEM1/YAL048C Protein Information Help

Standard Name Gem1p 1
Systematic Name Yal048cp
Alias Gon1p
ORF Classification Verified
Description Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases (1, 2, 3, 4)
Name Description GTPase EF-hand protein of Mitochondria 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 662
Molecular Weight (Da) 75,149
Isoelectric Point (pI) 5.85

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gem1p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013A054 | P39722
MIPS: YAL048C
NCBI: 595536 | 6319268 | 731284 | NP_009351.1
GenBank/EMBL/DDBJ: DAA06938.1 | U12980
External Classifications EC: 3.6.5.- [Hydrolases, Acting on GTP; involved in cellular and subcellular movement]
Amino Acid Sequence (or in FASTA format)
 
       1  MTKETIRVVI CGDEGVGKSS LIVSLTKAEF IPTIQDVLPP ISIPRDFSSS
      51  PTYSPKNTVL IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP
     101  HFRSLGLNIP VILCKNKCDS ISNVNANAMV VSENSDDDID TKVEDEEFIP
     151  ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ RAITHPISPL FDAMVGELKP
     201  LAVMALKRIF LLSDLNQDSY LDDNEILGLQ KKCFNKSIDV NELNFIKDLL
     251  LDISKHDQEY INRKLYVPGK GITKDGFLVL NKIYAERGRH ETTWAILRTF
     301  HYTDSLCIND KILHPRLVVP DTSSVELSPK GYRFLVDIFL KFDIDNDGGL
     351  NNQELHRLFK CTPGLPKLWT STNFPFSTVV NNKGCITLQG WLAQWSMTTF
     401  LNYSTTTAYL VYFGFQEDAR LALQVTKPRK MRRRSGKLYR SNINDRKVFN
     451  CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT IKPRIAVNSL ELKGGKQYYL
     501  ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL VSLLDKFTHL
     551  QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE
     601  LFIKITEAAL DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT
     651  LMKLFKSSKF SK*

external links for Gem1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Gem1p
1) Frederick RL, et al.  (2004) Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol 167(1):87-98
2) Wolff AM, et al.  (1999) The open reading frame YAL048c affects the secretion of proteinase A in S. cerevisiae. Yeast 15(5):427-34
3) Stroud DA, et al.  (2011) Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol 413(4):743-50
4) Kornmann B, et al.  (2011) The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A 108(34):14151-6