GCV3/YAL044C Protein Information

Standard Name	Gcv3p 1
Systematic Name	Yal044cp
ORF Classification	Verified
Description	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF (2, 3, 4)
Name Description	GlyCine cleaVage 1

Experimental Data
Molecules/cell	3510 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	170
Molecular Weight (Da)	18,793
Isoelectric Point (pI)	4.49

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gcv3p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000158F263 \| P39726 MIPS: YAL044C NCBI: 269970294 \| 311033448 \| 595540 \| 731280 \| NP_009355.3 \| NM_001178189.1 GenBank/EMBL/DDBJ: DAA06942.1 \| U12980

Amino Acid Sequence (or in FASTA format)
1 MLRTTRLWTT RMPTVSKLFL RNSSGNALNK NKLPFLYSSQ GPQAVRYTSQ 51 HEWIAVHQDK TAFVGITKYA TDALGDATYV ELPEVGTEIA QGESLGSIES 101 VKSASEIYQP ADGTVEEINT NLEENPGVVN EDPMGDGWLV KMKLGEGVNV 151 EQVEGLMSLE QYEKTLVHDD *

Amino Acid Sequence (or in FASTA format)

       1  MLRTTRLWTT RMPTVSKLFL RNSSGNALNK NKLPFLYSSQ GPQAVRYTSQ
      51  HEWIAVHQDK TAFVGITKYA TDALGDATYV ELPEVGTEIA QGESLGSIES
     101  VKSASEIYQP ADGTVEEINT NLEENPGVVN EDPMGDGWLV KMKLGEGVNV
     151  EQVEGLMSLE QYEKTLVHDD *

external links for Gcv3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gcv3p

1)	Nagarajan L and Storms RK (1997) Molecular characterization of GCV3, the Saccharomyces cerevisiae gene coding for the glycine cleavage system hydrogen carrier protein. J Biol Chem 272(7):4444-50
2)	Piper MD, et al. (2000) Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. J Biol Chem 275(40):30987-95
3)	Gelling CL, et al. (2004) Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. J Biol Chem 279(8):7072-81
4)	Schonauer MS, et al. (2009) Lipoic Acid synthesis and attachment in yeast mitochondria. J Biol Chem 284(35):23234-42
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41