CYC3/YAL039C Protein Information

Standard Name	Cyc3p
Systematic Name	Yal039cp
ORF Classification	Verified
Description	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) (1, 2)
Name Description	CYtochrome C
Gene Product	CCHL 3 , cytochrome c heme lyase 3

Experimental Data
Molecules/cell	3870 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	269
Molecular Weight (Da)	30,081
Isoelectric Point (pI)	5.26

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cyc3p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001272BA \| P06182 MIPS: YAL039C NCBI: 115944 \| 3616 \| 595545 \| 6319278 \| NP_009361.1 GenBank/EMBL/DDBJ: DAA06947.1 \| U12980 \| X04776
External Classifications	EC: 4.4.1.17 [Holocytochrome-c synthase]

Amino Acid Sequence (or in FASTA format)
1 MGWFWADQKT TGKDIGGAAV SSMSGCPVMH ESSSSSPPSS ECPVMQGDND 51 RINPLNNMPE LAASKQPGQK MDLPVDRTIS SIPKSPDSNE FWEYPSPQQM 101 YNAMVRKGKI GGSGEVAEDA VESMVQVHNF LNEGCWQEVL EWEKPHTDES 151 HVQPKLLKFM GKPGVLSPRA RWMHLCGLLF PSHFSQELPF DRHDWIVLRG 201 ERKAEQQPPT FKEVRYVLDF YGGPDDENGM PTFHVDVRPA LDSLDNAKDR 251 MTRFLDRMIS GPSSSSSAP*

Amino Acid Sequence (or in FASTA format)

       1  MGWFWADQKT TGKDIGGAAV SSMSGCPVMH ESSSSSPPSS ECPVMQGDND
      51  RINPLNNMPE LAASKQPGQK MDLPVDRTIS SIPKSPDSNE FWEYPSPQQM
     101  YNAMVRKGKI GGSGEVAEDA VESMVQVHNF LNEGCWQEVL EWEKPHTDES
     151  HVQPKLLKFM GKPGVLSPRA RWMHLCGLLF PSHFSQELPF DRHDWIVLRG
     201  ERKAEQQPPT FKEVRYVLDF YGGPDDENGM PTFHVDVRPA LDSLDNAKDR
     251  MTRFLDRMIS GPSSSSSAP*

external links for Cyc3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Cyc3p

1)	Dumont ME, et al. (1987) Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. EMBO J 6(1):235-41
2)	Dumont ME, et al. (1991) Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol 11(11):5487-96
3)	Bernard DG, et al. (2003) Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases. J Biol Chem 278(50):49732-42
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41