MTW1/YAL034W-A Protein Information

Standard Name	Mtw1p
Systematic Name	Yal034w-ap
Alias	Dsn3p , Nsl2p
ORF Classification	Verified
Description	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly (1)
Name Description	Mis TWelve-like 2

Experimental Data
Molecules/cell	2610 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	289
Molecular Weight (Da)	33,243
Isoelectric Point (pI)	4.96

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mtw1p (InterPro)
Physical Interactions	There are 103 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012F885 \| P39731 MIPS: YAL034W-A NCBI: 1326057 \| 1723189 \| 4887606 \| 6319283 \| NP_009367.1 \| NM_001178179.1 GenBank/EMBL/DDBJ: DAA06953.1 \| AB027473 \| U12980

Amino Acid Sequence (or in FASTA format)
1 MSAPTMRSTS ILTEHLGYPP ISLVDDIINA VNEIMYKCTA AMEKYLLSKS 51 KIGEEDYGEE IKSGVAKLES LLENSVDKNF DKLELYVLRN VLRIPEEYLD 101 ANVFRLENQK DLVIVDENEL KKSEEKLREK VNDVELAFKK NEMLLKRVTK 151 VKRLLFTIRG FKQKLNELLK CKDDVQLQKI LESLKPIDDT MTLLTDSLRK 201 LYVDSESTSS TEEVEALLQR LKTNGKQNNK DFRTRYIDIR TNNVLRKLGL 251 LGDKEDEKQS AKPDARTQAG DIVSIDIEEP QLDLLDDVL*

Amino Acid Sequence (or in FASTA format)

       1  MSAPTMRSTS ILTEHLGYPP ISLVDDIINA VNEIMYKCTA AMEKYLLSKS
      51  KIGEEDYGEE IKSGVAKLES LLENSVDKNF DKLELYVLRN VLRIPEEYLD
     101  ANVFRLENQK DLVIVDENEL KKSEEKLREK VNDVELAFKK NEMLLKRVTK
     151  VKRLLFTIRG FKQKLNELLK CKDDVQLQKI LESLKPIDDT MTLLTDSLRK
     201  LYVDSESTSS TEEVEALLQR LKTNGKQNNK DFRTRYIDIR TNNVLRKLGL
     251  LGDKEDEKQS AKPDARTQAG DIVSIDIEEP QLDLLDDVL*

external links for Mtw1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mtw1p

1)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21
2)	Goshima G and Yanagida M (2000) Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Cell 100(6):619-33
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41