FUN26/YAL022C Protein Information

Standard Name	Fun26p
Systematic Name	Yal022cp
ORF Classification	Verified
Description	Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis (1, 2)
Name Description	Function Unknown Now 3

Experimental Data
Molecules/cell	217 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	517
Molecular Weight (Da)	58,317
Isoelectric Point (pI)	4.79

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fun26p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012AD45 \| P31381 MIPS: YAL022C NCBI: 171853 \| 401440 \| 6319297 \| NP_009380.1 GenBank/EMBL/DDBJ: DAA06966.1 \| L05146
External Classifications	TC: 2.A.57.3

Amino Acid Sequence (or in FASTA format)
1 MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD 51 NYSEREQSVS TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ 101 YFKHDIFKDT SIWAKIFTSS MMSFSTISSM LFNIYLAKRQ YKYSRRVING 151 LVWEIIVFTV MCFFTILHFL LPKWFNFMFI MMLVVISSMG TAMTQNGIMA 201 IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS TTGGILLYFF 251 TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI 301 VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT 351 TFVVTLVFPV FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM 401 FRDQKFTPRK TFIYSLLRVA AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC 451 YMLLQFLFGV TNGHVISMSF MKVPEQLDND DEKEAAGGFT NIFVSTGLAL 501 GSIISYVFVF IIDFIIR*

Amino Acid Sequence (or in FASTA format)

       1  MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD
      51  NYSEREQSVS TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ
     101  YFKHDIFKDT SIWAKIFTSS MMSFSTISSM LFNIYLAKRQ YKYSRRVING
     151  LVWEIIVFTV MCFFTILHFL LPKWFNFMFI MMLVVISSMG TAMTQNGIMA
     201  IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS TTGGILLYFF
     251  TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI
     301  VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT
     351  TFVVTLVFPV FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM
     401  FRDQKFTPRK TFIYSLLRVA AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC
     451  YMLLQFLFGV TNGHVISMSF MKVPEQLDND DEKEAAGGFT NIFVSTGLAL
     501  GSIISYVFVF IIDFIIR*

external links for Fun26p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	TCDB
YGOB	DIP	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Fun26p

1)	Vickers MF, et al. (2000) Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes. J Biol Chem 275(34):25931-8
2)	Lu SP and Lin SJ (2011) Phosphate-responsive Signaling Pathway Is a Novel Component of NAD+ Metabolism in Saccharomyces cerevisiae. J Biol Chem 286(16):14271-81
3)	Coleman KG, et al. (1986) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome. Mol Cell Biol 6(12):4516-25
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41