PSK1/YAL017W Protein Information

Standard Name	Psk1p
Systematic Name	Yal017wp
Alias	Fun31p
ORF Classification	Verified
Description	PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Pas domain-containing Serine/threonine protein Kinase 2

Experimental Data
Molecules/cell	967 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,356
Molecular Weight (Da)	152,332
Isoelectric Point (pI)	5.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Psk1p (InterPro)
Physical Interactions	There are 45 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD25 \| P31374 MIPS: YAL017W NCBI: 171858 \| 330443380 \| 341941736 \| 400097 \| NP_009385.2 \| NM_001178162.2 GenBank/EMBL/DDBJ: DAA06971.2 \| L05146
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MPYIGASNLS EHSFVNLKEK HAITHKGTSS SVASLQTPPS PDQENHIDNE 51 LENYDTSLSD VSTPNKKEGD EFEQSLRDTF ASFRKTKPPP PLDFEQPRLP 101 STASSSVDST VSSPLTDEDI KELEFLPNES THSYSYNPLS PNSLAVRLRI 151 LKRSLEIIIQ NPSMLLEPTP DDLPPLKEFA GRRSSLPRTS ASANHLMNRN 201 KSQIWNTTSA TLNAFVNNTS SSSAASSALS NKKPGTPVFP NLDPTHSQTF 251 HRANSLAYLP SILPEQDPLL KHNNSLFRGD YGNNISPERP SFRQPFKDQT 301 SNLRNSSLLN ERAYQEDETF LPHHGPSMDL LNEQRANLKS LLNLLNETLE 351 KNTSERASDL HMISLFNLNK LMLGDPKKNN SERDKRTEKL KKILLDSLAE 401 PFFEHYNFIG DNPIADTDEL KEEIDEFTGS GDTTAITDIR PQQDYGRILR 451 TFTSTKNSAP QAIFTCSQED PWQFRAANDL ACLVFGISQN AIRALTLMDL 501 IHTDSRNFVL HKLLSTEGQE MVFTGEIIGI VQPETLSSSK VVWASFWAKR 551 KNGLLVCVFE KVPCDYVDVL LNLDDFGAEN IVDKCELLSD GPTLSSSSTL 601 SLPKMASSPT GSKLEYSLER KILEKSYTKP TSTENRNGDE NQLDGDSHSE 651 PSLSSSPVRS KKSVKFANDI KDVKSISQSL AKLMDDVRNG VVFDPDDDLL 701 PMPIKVCNHI NETRYFTLNH LSYNIPCAVS STVLEDELKL KIHSLPYQAG 751 LFIVDSHTLD IVSSNKSILK NMFGYHFAEL VGKSITEIIP SFPKFLQFIN 801 DKYPALDITL HKNKGLVLTE HFFRKIQAEI MGDRKSFYTS VGIDGLHRDG 851 CEIKIDFQLR VMNSKVILLW VTHSRDVVFE EYNTNPSQLK MLKESELSLM 901 SSASSSASSS KKSSSRISTG TLKDMSNLST YEDLAHRTNK LKYEIGDDSR 951 AHSQSTLSEQ EQVPLENDKD SGEMMLADPE MKHKLELARI YSRDKSQFVK 1001 EGNFKVDENL IISKISLSPS TESLADSKSS GKGLSPLEEE KLIDENATEN 1051 GLAGSPKDED GIIMTNKRGN QPVSTFLRTP EKNIGAQKHV KKFSDFVSLQ 1101 KMGEGAYGKV NLCIHKKNRY IVVIKMIFKE RILVDTWVRD RKLGTIPSEI 1151 QIMATLNKKP HENILRLLDF FEDDDYYYIE TPVHGETGCI DLFDLIEFKT 1201 NMTEFEAKLI FKQVVAGIKH LHDQGIVHRD IKDENVIVDS KGFVKIIDFG 1251 SAAYVKSGPF DVFVGTIDYA APEVLGGNPY EGQPQDIWAI GILLYTVVFK 1301 ENPFYNIDEI LEGDLKFNNA EEVSEDCIEL IKSILNRCVP KRPTIDDINN 1351 DKWLVI*

Amino Acid Sequence (or in FASTA format)

       1  MPYIGASNLS EHSFVNLKEK HAITHKGTSS SVASLQTPPS PDQENHIDNE
      51  LENYDTSLSD VSTPNKKEGD EFEQSLRDTF ASFRKTKPPP PLDFEQPRLP
     101  STASSSVDST VSSPLTDEDI KELEFLPNES THSYSYNPLS PNSLAVRLRI
     151  LKRSLEIIIQ NPSMLLEPTP DDLPPLKEFA GRRSSLPRTS ASANHLMNRN
     201  KSQIWNTTSA TLNAFVNNTS SSSAASSALS NKKPGTPVFP NLDPTHSQTF
     251  HRANSLAYLP SILPEQDPLL KHNNSLFRGD YGNNISPERP SFRQPFKDQT
     301  SNLRNSSLLN ERAYQEDETF LPHHGPSMDL LNEQRANLKS LLNLLNETLE
     351  KNTSERASDL HMISLFNLNK LMLGDPKKNN SERDKRTEKL KKILLDSLAE
     401  PFFEHYNFIG DNPIADTDEL KEEIDEFTGS GDTTAITDIR PQQDYGRILR
     451  TFTSTKNSAP QAIFTCSQED PWQFRAANDL ACLVFGISQN AIRALTLMDL
     501  IHTDSRNFVL HKLLSTEGQE MVFTGEIIGI VQPETLSSSK VVWASFWAKR
     551  KNGLLVCVFE KVPCDYVDVL LNLDDFGAEN IVDKCELLSD GPTLSSSSTL
     601  SLPKMASSPT GSKLEYSLER KILEKSYTKP TSTENRNGDE NQLDGDSHSE
     651  PSLSSSPVRS KKSVKFANDI KDVKSISQSL AKLMDDVRNG VVFDPDDDLL
     701  PMPIKVCNHI NETRYFTLNH LSYNIPCAVS STVLEDELKL KIHSLPYQAG
     751  LFIVDSHTLD IVSSNKSILK NMFGYHFAEL VGKSITEIIP SFPKFLQFIN
     801  DKYPALDITL HKNKGLVLTE HFFRKIQAEI MGDRKSFYTS VGIDGLHRDG
     851  CEIKIDFQLR VMNSKVILLW VTHSRDVVFE EYNTNPSQLK MLKESELSLM
     901  SSASSSASSS KKSSSRISTG TLKDMSNLST YEDLAHRTNK LKYEIGDDSR
     951  AHSQSTLSEQ EQVPLENDKD SGEMMLADPE MKHKLELARI YSRDKSQFVK
    1001  EGNFKVDENL IISKISLSPS TESLADSKSS GKGLSPLEEE KLIDENATEN
    1051  GLAGSPKDED GIIMTNKRGN QPVSTFLRTP EKNIGAQKHV KKFSDFVSLQ
    1101  KMGEGAYGKV NLCIHKKNRY IVVIKMIFKE RILVDTWVRD RKLGTIPSEI
    1151  QIMATLNKKP HENILRLLDF FEDDDYYYIE TPVHGETGCI DLFDLIEFKT
    1201  NMTEFEAKLI FKQVVAGIKH LHDQGIVHRD IKDENVIVDS KGFVKIIDFG
    1251  SAAYVKSGPF DVFVGTIDYA APEVLGGNPY EGQPQDIWAI GILLYTVVFK
    1301  ENPFYNIDEI LEGDLKFNNA EEVSEDCIEL IKSILNRCVP KRPTIDDINN
    1351  DKWLVI*

external links for Psk1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Psk1p

1)	Rutter J (2002) Essay: Amersham Biosciences and Science Prize. PAS domains and metabolic status signaling. Science 298(5598):1567-8
2)	Rutter J, et al. (2002) Coordinate regulation of sugar flux and translation by PAS kinase. Cell 111(1):17-28
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41