ERP2/YAL007C Protein Information

Standard Name	Erp2p 1
Systematic Name	Yal007cp
ORF Classification	Verified
Description	Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Emp24p/Erv25p Related Protein 1

Experimental Data
Molecules/cell	26300 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	215
Molecular Weight (Da)	24,063
Isoelectric Point (pI)	4.83

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Erp2p (InterPro)
Transmembrane Domains	There are 2 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 65 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F11 \| P39704 MIPS: YAL007C NCBI: 349746 \| 45270222 \| 6319312 \| 731264 \| NP_009395.1 \| NM_001178152.1 GenBank/EMBL/DDBJ: DAA06981.1 \| AY558166 \| L22015

Amino Acid Sequence (or in FASTA format)
1 MIKSTIALPS FFIVLILALV NSVAASSSYA PVAISLPAFS KECLYYDMVT 51 EDDSLAVGYQ VLTGGNFEID FDITAPDGSV ITSEKQKKYS DFLLKSFGVG 101 KYTFCFSNNY GTALKKVEIT LEKEKTLTDE HEADVNNDDI IANNAVEEID 151 RNLNKITKTL NYLRAREWRN MSTVNSTESR LTWLSILIII IIAVISIAQV 201 LLIQFLFTGR QKNYV*

Amino Acid Sequence (or in FASTA format)

       1  MIKSTIALPS FFIVLILALV NSVAASSSYA PVAISLPAFS KECLYYDMVT
      51  EDDSLAVGYQ VLTGGNFEID FDITAPDGSV ITSEKQKKYS DFLLKSFGVG
     101  KYTFCFSNNY GTALKKVEIT LEKEKTLTDE HEADVNNDDI IANNAVEEID
     151  RNLNKITKTL NYLRAREWRN MSTVNSTESR LTWLSILIII IIAVISIAQV
     201  LLIQFLFTGR QKNYV*

external links for Erp2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Erp2p

1)	Marzioch M, et al. (1999) Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell 10(6):1923-38
2)	Springer S, et al. (2000) The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 97(8):4034-9
3)	Otte S, et al. (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41