MET1/YKR069W Locus History Help


Nomenclature History
Standard Name Reference
MET1 Hansen J, et al.  (1997) Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. FEBS Lett 401(1):20-4 Masselot M and De Robichon-Szulmajster H  (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
Other Name(s)Reference
MET20 Hansen J, et al.  (1997) Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. FEBS Lett 401(1):20-4 Masselot M and De Robichon-Szulmajster H  (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32 Masselot M and Surdin-Kerjan Y  (1977) Methionine biosynthesis in Saccharomyces cerevisiae. II. Gene-enzyme relationships in the sulfate assimilation pathway. Mol Gen Genet 154(1):23-30
Sequence Annotation Notes
DateNote
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the stop site for MET1/YKR069W be moved 6 nt upstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: 1) the S. cerevisiae C-terminus is extended only two amino acids beyond that predicted for the other species, and there is very close protein conservation up to that point, it is very possible that the difference in S. cerevisiae represents normal variation among species; 2) a sequencing error would introduce a stop codon that would align with the other three species. Any proposed S. cerevisiae sequencing error(s) must be confirmed in S288C before the annotation is changed.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54