BET4/YJL031C Locus History Help


Nomenclature History
Standard Name Reference
BET4 Jiang Y, et al.  (1995) BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae. J Biol Chem 270(37):21793-9
Nomenclature History Notes
DateNote
2002-07-16The genetically-defined MAD2 gene was originally identified as YJL031C (see Li R, et al. (1993) Nature 366(6450):82-4, and erratum in Nature (1994) 371(6496):438). It is now known that MAD2, involved in the mitotic spindle checkpoint, is equivalent to YJL030W, while YJL031C/BET4 encodes the alpha subunit of geranylgeranyltransferase type II.
Sequence Annotation Notes
DateNote
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for BET4/YJL031C be moved 165 nt downstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: 1) The sequence analysis is inconclusive because only S. mikatae and S. paradoxus are predicted to use the suggested start site. S. bayanus is predicted to use an upstream start methionine; 2) The N-terminal 55 amino acids in BET4/YJL031C have homology to other proteins (see PDB homologs for BET4/YJL031C) which argues that they are protein coding.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
2004-01-27Moved start 198 bp upstream, added an intron which was previously absent from the annotation. Encoded protein is 327 aa, as opposed to the previously annotated 290 aa.

Brachat S, et al.  (2003) Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. Genome Biol 4(7):R45