JIP5/YPR169W Locus History Help


Nomenclature History
An SGD Standard Name was first assigned to this gene on 2006-12-12.
Standard Name Reference
JIP5 Tronnersjo S, et al.  (2007) The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair. Mol Genet Genomics 277(1):57-70
Sequence Annotation Notes
DateNote
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for YPR169W be moved 66 nt downstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: 1) Sequence comparisons are inconclusive because the currently annotated S. cerevisiae start methionine is conserved in S. paradoxus, S. mikatae, and S. bayanus orthologs, as is the sequence surrounding it. This suggests that the start in SGD is correct. However, frameshifts in the S. mikatae, S. bayanus sequences before the second ATG, and sequence conservation surrounding the second ATG suggest that a change in S. cerevisiae coordinates is called for. Resequencing of one or more strains will be required to resolve this issue.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
2005-12-01The work of Zhang & Dietrich 2005 confirmed the suggestion from Kellis et al. 2003 that the start site of YPR169W be moved 66 nt downstream from 878620 to 878686. This annotation change results in a predicted protein of 492 aa, as opposed to the previously annotated 514 aa.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
Zhang Z and Dietrich FS  (2005) Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE. Nucleic Acids Res 33(9):2838-51