MCA1/YOR197W Locus History Help


Nomenclature History
An SGD Standard Name was first assigned to this gene on 2002-04-30.
Standard Name Reference
MCA1 Szallies A, et al.  (2002) A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae. FEBS Lett 517(1-3):144-50
Other Name(s)Reference
YCA1 Madeo F, et al.  (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9(4):911-7
Sequence Annotation Notes
DateNote
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for YOR197W be moved 57 nt downstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: 1) There is not an ATG present in the proposed position in S. cerevisiae or any of the other Saccharomyces species, although there is a conserved methionine 63 nt downstream of the currently annotated S. cerevisiae; 2) S. paradoxus is predicted to use a start methionine that is upstream of that predicted for S. bayanus and S. paradoxus.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
2010-04-07Although the shorter form of Mca1p is expressed under physiological conditions, a longer isoform increases aggregation.

Erhardt M, et al.  (2010) Extra N-terminal residues have a profound effect on the aggregation properties of the potential yeast prion protein mca1. PLoS One 5(3):e9929
2006-05-11The proposal by Kellis et al. was re-examined in light of sequence data from S. kudriavzevii (another sensu stricto strain published by Cliften et al.). The S. kudriavzevii sequence supported the start codon suggested by Kellis et al., so the start site for MCA1/YOR197W was moved 57 nt (19 amino acids) downstream.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
Cliften P, et al.  (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6