ZIM17/YNL310C Locus History

Nomenclature History
An SGD Standard Name was first assigned to this gene on 2004-11-22.
Standard Name	Reference
ZIM17	Burri L, et al. (2004) Zim17, a novel zinc finger protein essential for protein import into mitochondria. J Biol Chem 279(48):50243-9

Other Name(s)	Reference
FMP28	Chacinska, A., et al. (2004) personal communication
HEP1	Sichting M, et al. (2005) Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J 24(5):1046-56
TIM15	Yamamoto H, et al. (2005) Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane. FEBS Lett 579(2):507-11

Nomenclature History Notes
Date	Note
2004-09-24	FMP28 was a reserved name for YNL310C from October 2003 to September 2004. The reservation was removed at the request of the author, and FMP28 has been retired.

Sequence Annotation Notes
Date	Note
2003-12-01	Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for YNL310C be moved 93 nt downstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: 1) Although S. bayanus and S. mikatae both share the same start methionine, the start codon predicted for S. paradoxus is slightly upstream; 2) This protein is unusually poorly conserved at the N-terminus, making it difficult to conclude that the S. cerevisiae annotation should be changed, based on sequence analysis alone.
	Kellis M, et al. (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
2004-11-22	Burri et al. have now provided experimental evidence supporting the re-annotation of the YNL310C start codon to a position 93 nt downstream of its currently annotated position.
	Burri L, et al. (2004) Zim17, a novel zinc finger protein essential for protein import into mitochondria. J Biol Chem 279(48):50243-9
2006-05-10	The proposal by Kellis et al. was re-examined in light of sequence data from S. kudriavzevii (another sensu stricto strain published by Cliften et al.). The S. kudriavzevii sequence supported the start codon suggested by Kellis et al., so the start site for ZIM17/YNL310C be moved 93 nt (31 amino acids) downstream.
	Kellis M, et al. (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
	Cliften P, et al. (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6