ATG4/YNL223W Locus History Help

Nomenclature History
Standard Name Reference
ATG4 Klionsky DJ, et al.  (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
Other Name(s)Reference
APG4 Tsukada M and Ohsumi Y  (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
AUT2 Thumm M, et al.  (1994) Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett 349(2):275-80
Nomenclature History Notes
2001-03-16APG4 is allelic to AUT2. Kirisako T, et al. (1999). J. Cell Biology 147(2):435-446.
2003-09-10The standard gene name of ORF YNL223W was changed from AUT2 to ATG4, as part of the unified autophagy nomenclature agreed upon by the yeast research community. Sept. 10, 2003
Sequence Annotation Notes
2003-09-22Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for ATG4/YNL223W be moved 36 nt (12 codons) downstream. This suggestion was reviewed and accepted by SGD curators. The numbering for both the nucleotides in the DNA coding sequence and the amino acids in the predicted protein have been changed accordingly. Evidence supporting this change includes: 1) This is the predicted start methionine in the majority of Saccharomyces species orthologs analyzed by Kellis et al. and/or Cliften et al.; 2) Significant sequence conservation begins abruptly at this predicted start methionine; 3) The first ATG is not conserved in S. paradoxus, S. mikatae, and S. bayanus; 4) In an independent Genbank record also uses the second ATG for the protein translation (Version AAA86498.1 GI:1173491).

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
Cliften P, et al.  (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6