STP1/YDR463W Locus History Help

Nomenclature History
Standard Name Reference
STP1 Wang SS and Hopper AK  (1988) Isolation of a yeast gene involved in species-specific pre-tRNA processing. Mol Cell Biol 8(12):5140-9
Other Name(s)Reference
SSY2 Jorgensen MU, et al.  (1998) Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14(2):103-14
Sequence Annotation Notes
2003-09-22Based on the automated comparison of closely-related Saccharomyces species by Kellis et al., the start site for STP1/YDR463W was moved 174 nt (58 codons) downstream. Evidence supporting this change includes: 1) This is the predicted start methionine in the majority of Saccharomyces species orthologs analyzed by Kellis et al. and/or Cliften et al.; 2) Significant sequence conservation begins abruptly at this predicted start methionine; 3) Previously published data from Wang et al. demonstrate that the second in frame methionine is the most likely start codon.

Wang SS, et al.  (1992) STP1, a gene involved in pre-tRNA processing, encodes a nuclear protein containing zinc finger motifs. Mol Cell Biol 12(6):2633-43
Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
Cliften P, et al.  (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6
Mapping Notes
1992-10-01Edition 11: stp1 is immediately upstream of spp41; the order of these two genes relative to prp3 (rna3) and snf1 is unknown

Mortimer RK, et al.  (1992) Genetic and physical maps of Saccharomyces cerevisiae, Edition 11. Yeast 8(10):817-902