SIR4/YDR227W Locus History Help

Nomenclature History
Standard Name Reference
SIR4 Rine J and Herskowitz I  (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22
Sequence Annotation Notes
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the stop site for SIR4/YDR227W be moved 11 nt upstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: Although the DNA sequences of all four species S. cerevisiae, S. paradoxus, S. mikatae, and S. bayanus are very similar within the region at the end of the ORF, S. cerevisiae contains a 1 base insertion with respect to the other three species 35 nt upstream of the current stop site. If this base were removed from the S. cerevisiae the resulting predicted protein sequence would end in the same position as those of the other three species. Proposed S. cerevisiae sequencing error(s) must be confirmed in S288C before the annotation is changed.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
Mapping Notes
1989-10-01Edition 10: sir4 data in 1985 mapping review; new reference

Mortimer RK, et al.  (1989) Genetic map of Saccharomyces cerevisiae, edition 10. Yeast 5(5):321-403