TRS85/YDR108W Locus History

Nomenclature History
Standard Name	Reference
TRS85	Sacher M, et al. (2000) Identification and characterization of five new subunits of TRAPP. Eur J Cell Biol 79(2):71-80

Other Name(s)	Reference
GSG1	Kaytor MD and Livingston DM (1995) GSG1, a yeast gene required for sporulation. Yeast 11(12):1147-55
MUM1	Engebrecht J, et al. (1998) Yeast meiotic mutants proficient for the induction of ectopic recombination. Genetics 148(2):581-98

Nomenclature History Notes
2011-02-07	YDR108W was originally named GSG1 (General Sporulation Gene), based on its identification as a spontaneously arising sporulation defective mutant with delayed pre-meiotic DNA synthesis. The name was changed to TRS85 (TRapp Subunit) in February 2011 based on a request from the community. This change was requested as the name TRS85 is more frequently used in the literature by yeast researchers, and more accurately reflects the function of this 85 kD protein as a subunit of TRAPP (TRAnsport Protein Particle or TRAfficking Protein Particle). TRS85 was identified in screens for mutants defective in the cytoplasm-to-vacuole transport (CVT) pathway, macroautophagy and pexophagy. It was also found to be a specific component of TRAPPIII, a form of TRAPP that functions as an autophagy-specific GEF for Ypt1p and is required for a membrane-tethering event associated with CVT vesicle and autophagosome formation.

Nomenclature History Notes

Date

Note

2011-02-07

YDR108W was originally named GSG1 (General Sporulation Gene), based on its identification as a spontaneously arising sporulation defective mutant with delayed pre-meiotic DNA synthesis. The name was changed to TRS85 (TRapp Subunit) in February 2011 based on a request from the community. This change was requested as the name TRS85 is more frequently used in the literature by yeast researchers, and more accurately reflects the function of this 85 kD protein as a subunit of TRAPP (TRAnsport Protein Particle or TRAfficking Protein Particle). TRS85 was identified in screens for mutants defective in the cytoplasm-to-vacuole transport (CVT) pathway, macroautophagy and pexophagy. It was also found to be a specific component of TRAPPIII, a form of TRAPP that functions as an autophagy-specific GEF for Ypt1p and is required for a membrane-tethering event associated with CVT vesicle and autophagosome formation.

Mapping Notes
Date	Note
1996-09-21	Edition 13: chromosome 4R between SWI5 and STE5
	Cherry JM, et al. (1996) "Genetic and Physical Maps of Saccharomyces cerevisiae (Edition 13)". Pp. 361-364 in 1996 Yeast Genetics and Molecular Biology Meeting Program and Abstracts. Bethesda, MD: The Genetics Society of America