MAK11/YKL021C Locus History Help

Nomenclature History
Standard Name Reference
MAK11 Icho T, et al.  (1986) Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Basic Life Sci 40:165-71
Sequence Annotation Notes
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for MAK11/YKL021C be moved 162 nt downstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data because a detailed deletion analysis (Icho & Wickner 1988) identified that the first ATG is essential because a deletion of the first 40 nucleotides results in a null phenotype.

Icho T and Wickner RB  (1988) The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. J Biol Chem 263(3):1467-75
Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54