PTC7/YHR076W Locus History Help


Nomenclature History
An SGD Standard Name was first assigned to this gene on 2002-09-30.
Standard Name Reference
PTC7 Jiang L, et al.  (2002) The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast. FEBS Lett 527(1-3):323-5
Sequence Annotation Notes
DateNote
2007-07-09An intron was annotated within PTC7/YHR076W at relative coordinates 56..148 based on GenBank EF123135, Juneau et al. 2007, and Zhang et al. 2007. According to Juneau et al. 2007, the intron is "inefficiently spliced" (splicing rate = 55%). Note that the currently annotated start and stop remain the same.

Juneau K, et al.  (2007) High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing. Proc Natl Acad Sci U S A 104(5):1522-7
Zhang Z, et al.  (2007) Genome-wide identification of spliced introns using a tiling microarray. Genome Res 17(4):503-9
2009-07-06PTC7 is alternatively spliced to produce two different proteins. Protein from the spliced isoform localizes to the mitochondrion, while the protein from the unspliced form localizes to the nuclear envelope

Juneau K, et al.  (2009) Alternative splicing of PTC7 in Saccharomyces cerevisiae determines protein localization. Genetics 183(1):185-94