GIM4/YEL003W Locus History Help

Nomenclature History
Standard Name Reference
GIM4 Geissler S, et al.  (1998) A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J 17(4):952-66
Sequence Annotation Notes
2003-12-01Based on the automated comparison of closely related Saccharomyces species, Kellis et al. suggest that the start site for GIM4/YEL003W be moved 198 nt downstream. This suggestion was reviewed by SGD curators, but will not be incorporated until supported by experimental data. The reason(s) for this decision are as follows: 1) The resulting ORF encodes less than 100 amino acids.

Kellis M, et al.  (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
2007-07-09The start of GIM4/YEL003W was moved 52 nt upstream, and an intron was added at relative coordinates 20-107, based on GenBank EF123144, Juneau et al. 2007, and Miura et al. 2006. According to Juneau et al. 2007, the intron is "inefficiently spliced" (splicing rate = 72%).The old coding coordinates were 148227..148598 (372 nt, 123 aa), and the new coding coordinates are 148175..148193,148282..148598 (1..19,108..424; 111 aa).

Miura F, et al.  (2006) A large-scale full-length cDNA analysis to explore the budding yeast transcriptome. Proc Natl Acad Sci U S A 103(47):17846-51
Juneau K, et al.  (2007) High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing. Proc Natl Acad Sci U S A 104(5):1522-7