YPT10/YBR264C Locus History

Nomenclature History
Standard Name	Reference
YPT10	Louvet O, et al. (1999) Characterization of the ORF YBR264c in Saccharomyces cerevisiae, which encodes a new yeast Ypt that is degraded by a proteasome-dependent mechanism. Mol Gen Genet 261(4-5):589-600 Lazar T, et al. (1997) Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? Trends Biochem Sci 22(12):468-72

Sequence Annotation Notes
Date	Note
2008-10-30	Data from Nagalakshmi et al. 2008 suggest that there is an in-frame AUG 19 codons upstream of the currently annotated AUG for either all or some of the transcripts of YPT10/YBR264C. The upstream AUG represents the previously annotated start for this ORF; the annotation of which was changed based on comparative DNA sequence data from Kellis et al. 2003 and/or Cliften et al. 2003.
	Kellis M, et al. (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
	Cliften P, et al. (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6
	Nagalakshmi U, et al. (2008) The transcriptional landscape of the yeast genome defined by RNA sequencing. Science 320(5881):1344-9
2003-09-22	The start site for YPT10/YBR264C was moved 57 nt (19 codons) downstream based on the automated comparison of closely-related Saccharomyces species by Kellis et al. Evidence supporting this change includes: 1) This is the predicted start methionine in the majority of Saccharomyces species orthologs analyzed by Kellis et al. and/or Cliften et al.; 2) Significant sequence conservation begins abruptly at this predicted start methionine.
	Kellis M, et al. (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54
	Cliften P, et al. (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6