TIF3/YPR163C Summary

TIF3 BASIC INFORMATION

Standard Name	TIF3
Systematic Name	YPR163C
Alias	RBL3 , STM1
Feature Type	ORF, Verified
Description	Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA (1, 2)
Name Description	Translation Initiation Factor

GO Annotations	All TIF3 GO evidence and references
	View Computational GO annotations for TIF3
Molecular Function
Manually curated	RNA binding (IDA) RNA strand annealing activity (IDA) translation initiation factor activity (ISS)
Biological Process
Manually curated	translation (IMP) translational initiation (IDA, IGI, IMP, ISS)
Cellular Component
Manually curated	ribosome (TAS)

Mutant Phenotype	All TIF3 Phenotype details and references
Large-scale survey
null	acid pH resistance: decreased bud morphology: abnormal polyphosphate accumulation: abnormal competitive fitness: decreased metal resistance: decreased resistance to oleate: decreased resistance to monensin: decreased viable

Interactions	TIF3 All interactions details and references
	33 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 1 Phenotypic Enhancement: 4 Phenotypic Suppression: 6 Synthetic Growth Defect: 2 Synthetic Lethality: 4 Synthetic Rescue: 1

Sequence Information

ChrXVI:869951 to 868641 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1311	869951..868641	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006367

TIF3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TIF3

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
STM1	Nomenclature conflict	Both YPR163C/TIF3 and YLR150W/STM1 have been referred to as STM1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TIF3]

1)	Coppolecchia R, et al. (1993) A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase. EMBO J 12(10):4005-11
2)	Altmann M, et al. (1995) The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity. EMBO J 14(15):3820-7

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