SFH1/YLR321C Summary

SFH1 BASIC INFORMATION

Standard Name	SFH1
Systematic Name	YLR321C
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog (1, 2, 3, 4, 5)
Name Description	Snf Five Homolog

GO Annotations	All SFH1 GO evidence and references
	View Computational GO annotations for SFH1
Molecular Function
Manually curated	contributes_to DNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) chromatin remodeling at centromere (IMP) chromosome segregation (IGI) double-strand break repair (IMP) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) regulation of DNA replication during S phase (IGI) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)

Mutant Phenotype	All SFH1 Phenotype details and references
Classical genetics
repressible	cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
null	inviable

Interactions	SFH1 All interactions details and references
	83 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 63 Affinity Capture-Western: 5 Co-purification: 2 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Synthetic Growth Defect: 3

Sequence Information

ChrXII:777864 to 776584 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1281	777864..776584	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004313

SFH1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SFH1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
YKL091C	Nomenclature conflict	Both YLR321C/SFH1 and YKL091C have been referred to as SFH1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SFH1]

1)	Cao Y, et al. (1997) Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression. Mol Cell Biol 17(6):3323-34
2)	Cairns BR, et al. (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
3)	Lorch Y, et al. (1999) Histone octamer transfer by a chromatin-remodeling complex. Cell 96(3):389-92
4)	Hsu JM, et al. (2003) The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol 23(9):3202-15
5)	Campsteijn C, et al. (2007) Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance. PLoS Genet 3(6):e92

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