SPR3/YGR059W Summary Help

SPR3 BASIC INFORMATION

Standard Name SPR3
Systematic Name YGR059W
Feature Type ORF, Verified
Description Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI (1 and see Summary Paragraph)
Name Description SPorulation Regulated 2
GO Annotations All SPR3 GO evidence and references
    View Computational GO annotations for SPR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPR3 Phenotype details and references
Large-scale survey
null
Interactions SPR3 All interactions details and references
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Two-hybrid: 2
Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
Sequence Information
ChrVII:607567 to 609105 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1539 607567..609105 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003291

SPR3 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPR3

SUMMARY PARAGRAPH for SPR3

SPR3 encodes a septin (3). Septins are a family of conserved proteins first identified in yeast and subsequently found in numerous other fungi and animals, including human, mouse, Drosophila, and C. elegans (reviewed in 4 and 5). Four yeast septins, Cdc3p Cdc10p, Cdc11p, and Cdc12p, have been studied extensively; they are required for cytokinesis, axial bud site selection, and the correct localization of several other proteins involved in cytokinesis, morphogenesis, and bud site selection (5, 6).

SPR3 is expressed specifically during meiotic divisions and ascospore formation (7). Deletion of SPR3 causes no apparent defect in mitotically growing cells, but causes a sporulation defect in some strains (3). The septins Spr3p and Spr28p localize to the prospore wall along with Cdc3p and Cdc11p (3, 8).

Last updated: 1999-12-09

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPR3]

1) Ozsarac N, et al.  (1995) The SPR3 gene encodes a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilaments and is regulated by ABFI. Gene 164(1):157-62
2) Holaway BL, et al.  (1987) Transcriptional regulation of sporulation genes in yeast. Mol Gen Genet 210(3):449-59
3) Fares H, et al.  (1996) Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. J Cell Biol 132(3):399-411
4) Longtine MS, et al.  (1996) The septins: roles in cytokinesis and other processes. Curr Opin Cell Biol 8(1):106-19
5) Field CM and Kellogg D  (1999) Septins: cytoskeletal polymers or signalling GTPases? Trends Cell Biol 9(10):387-94
6) Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744
7) Ozsarac N, et al.  (1997) Regulation of gene expression during meiosis in Saccharomyces cerevisiae: SPR3 is controlled by both ABFI and a new sporulation control element. Mol Cell Biol 17(3):1152-9
8) De Virgilio C, et al.  (1996) SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology 142 ( Pt 10):2897-905