PSO2/YMR137C Summary Help

Standard Name PSO2 1
Systematic Name YMR137C
Alias SNM1 2
Feature Type ORF, Verified
Description Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress (3, 4, 5, 6, 7, 8, 9, 10)
Name Description PSOralen derivative sensitive 1
Chromosomal Location
ChrXIII:544963 to 542978 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All PSO2 GO evidence and references
  View Computational GO annotations for PSO2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
47 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 5
  • Phenotypic Enhancement: 24
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 6
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 661
Molecular Weight (Da) 76,398
Isoelectric Point (pI) 7.85
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:544963 to 542978 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1986 544963..542978 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004745
References cited on this page View Complete Literature Guide for PSO2
1) Henriques JA and Moustacchi E  (1980) Isolation and characterization of pso mutants sensitive to photo-addition of psoralen derivatives in Saccharomyces cerevisiae. Genetics 95(2):273-88
2) Cassier-Chauvat C and Moustacchi E  (1988) Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiae. Curr Genet 13(1):37-40
3) Cassier C and Moustacchi E  (1981) Mutagenesis induced by mono- and bi-functional alkylating agents in yeast mutants sensitive to photo-addition of furocoumarins (pso). Mutat Res 84(1):37-47
4) Wilborn F and Brendel M  (1989) Formation and stability of interstrand cross-links induced by cis- and trans-diamminedichloroplatinum (II) in the DNA of Saccharomyces cerevisiae strains differing in repair capacity. Curr Genet 16(5-6):331-8
5) Angulo JF, et al.  (1986) Induction of polypeptides in Saccharomyces cerevisiae after ultraviolet irradiation. Biochem Biophys Res Commun 138(2):679-86
6) Magana-Schwencke N, et al.  (1982) The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strains. Proc Natl Acad Sci U S A 79(6):1722-6
7) Li X and Moses RE  (2003) The beta-lactamase motif in Snm1 is required for repair of DNA double-strand breaks caused by interstrand crosslinks in S. cerevisiae. DNA Repair (Amst) 2(1):121-9
8) Brendel M, et al.  (2003) Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae. Mutat Res 544(2-3):179-93
9) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
10) Ward TA, et al.  (2012) Components of a fanconi-like pathway control pso2-independent DNA interstrand crosslink repair in yeast. PLoS Genet 8(8):e1002884